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Wikipedia

Histona deacetilasa 1

La histona deacetilasa 1 (HDAC1) es una enzima codificada en humanos por el gen hdac1.[1]

Histona deacetilasa 1
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

 Lista de códigos PDB
4BKX
 Estructuras enzimáticas
RCSB PDB, PDBe, PDBsum
Identificadores
Símbolos HDAC1 (HGNC: 4852) DKFZp686H12203; GON-10; HD1; RPD3; RPD3L1
Identificadores
externos
 Bases de datos de enzimas
IntEnz: entrada en IntEnz
BRENDA: entrada en BRENDA
ExPASy: NiceZime view
KEGG: entrada en KEEG
PRIAM: perfil PRIAM
ExplorEnz: entrada en ExplorEnz
MetaCyc: vía metabólica
Número EC 3.5.1.98
Locus Cr. 1 p35.1
Patrón de expresión de ARNm
Más información
Ortólogos
Especies
Entrez
3065 433759
Ensembl
Véase HS Véase MM
UniProt
Q13547 O09106
RefSeq
(ARNm)
NM_004964 NM_008228
RefSeq
(proteína) NCBI
NP_004955 NP_032254
Ubicación (UCSC)
Cr. 1:
32.76 – 32.8 Mb
Cr. 4:
129.52 – 129.54 Mb
PubMed (Búsqueda)

Función

Las histonas juegan un papel crucial en la regulación de la transcripción, en la progresión del ciclo celular y en procesos de desarrollo. La acetilación/desacetilación de histonas altera la estructura del cromosoma, variando así la accesibilidad de los factores de transcripción al ADN. La HDAC1 pertenece a la familia de histona deacetilasas acuc/alfa y es uno de los componentes del complejo histona deacetilasa. Esta proteína interacciona con la proteína del retinoblastoma formando un complejo que es un elemento clave en el control de la proliferación celular y la diferenciación celular. Junto con la proteína 2 asociada a metástasis, deacetila a p53 y modula su acción sobre la proliferación celular y la apoptosis.[2]

Interacciones

La histona deacetilasa 1 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

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Enlaces externos

  • MeSH: HDAC1+protein,+human (en inglés)
  •   Datos: Q14914420

histona, deacetilasa, histona, deacetilasa, hdac1, enzima, codificada, humanos, hdac1, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsb, lista, códigos, pdb4bkx, estructuras, enzimáticasrcsb, pdbe, pdbsumidentificadoressímboloshdac1, hgnc, 4852, dkfzp6. La histona deacetilasa 1 HDAC1 es una enzima codificada en humanos por el gen hdac1 1 Histona deacetilasa 1Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB4BKX Estructuras enzimaticasRCSB PDB PDBe PDBsumIdentificadoresSimbolosHDAC1 HGNC 4852 DKFZp686H12203 GON 10 HD1 RPD3 RPD3L1IdentificadoresexternosOMIM 601241MGI 108086HomoloGene 68426ChEMBL 325EBI HDAC1GeneCards Gen HDAC1UniProt HDAC1 Bases de datos de enzimasIntEnz entrada en IntEnz BRENDA entrada en BRENDA ExPASy NiceZime view KEGG entrada en KEEG PRIAM perfil PRIAM ExplorEnz entrada en ExplorEnz MetaCyc via metabolicaNumero EC3 5 1 98LocusCr 1 p35 1 Ontologia genicaReferencias AmiGO QuickGOPatron de expresion de ARNmMas informacionOrtologosEspeciesHumano RatonEntrez3065 433759EnsemblVease HS Vease MMUniProtQ13547 O09106RefSeq ARNm NM 004964 NM 008228RefSeq proteina NCBINP 004955 NP 032254Ubicacion UCSC Cr 1 32 76 32 8 Mb Cr 4 129 52 129 54 MbPubMed Busqueda 1 2 vte editar datos en Wikidata Indice 1 Funcion 2 Interacciones 3 Vease tambien 4 Referencias 5 Enlaces externosFuncion EditarLas histonas juegan un papel crucial en la regulacion de la transcripcion en la progresion del ciclo celular y en procesos de desarrollo La acetilacion desacetilacion de histonas altera la estructura del cromosoma variando asi la accesibilidad de los factores de transcripcion al ADN La HDAC1 pertenece a la familia de histona deacetilasas acuc alfa y es uno de los componentes del complejo histona deacetilasa Esta proteina interacciona con la proteina del retinoblastoma formando un complejo que es un elemento clave en el control de la proliferacion celular y la diferenciacion celular Junto con la proteina 2 asociada a metastasis deacetila a p53 y modula su accion sobre la proliferacion celular y la apoptosis 2 Interacciones EditarLa histona deacetilasa 1 ha demostrado ser capaz de interaccionar con RAD9A 3 DNMT3L 4 5 MTA1 6 7 FKBP3 8 CDC20 9 CDH1 9 HCFC1 10 BUB3 9 NCOR2 11 12 IKZF1 13 14 Prohibitina 15 16 EVI1 17 18 DDX5 19 DNMT3A 20 SMAD2 21 HDAC2 22 6 23 24 25 26 11 27 28 29 30 31 32 MIER1 33 SIN3A 34 6 35 36 37 38 39 28 40 29 30 41 42 43 Proteina 6 asociada a muerte 44 Receptor androgenico 45 HMG20B 22 HUS1 3 IFRD1 46 MLL 47 ING1 48 43 MyoD 49 50 GATA1 51 SPEN 52 MAD1L1 9 Proteina de la leucemia promielocitica 53 54 CHD3 29 43 Homeoproteina TGIF1 55 56 Proteina del retinoblastoma like 2 57 58 Proteina del retinoblastoma like 1 59 57 CHD4 6 37 29 RCOR1 22 39 RBBP7 6 60 28 31 RFC1 61 Proteina del retinoblastoma 62 63 49 16 64 59 57 RBBP4 34 6 65 37 39 66 60 28 40 30 31 EED 32 PHF21A 22 67 SIN3B 28 13 RELA 68 69 27 NFKB1 69 BUB1B 9 Mdm2 70 SATB1 41 HSPA4 25 SUV39H1 71 BUB1 9 MBD2 72 60 28 ZBTB16 73 74 75 DDX17 19 BCL6 74 76 SUDS3 35 77 SAP30 78 79 28 80 81 43 Sp1 82 83 40 84 MTA2 6 39 28 41 PCNA 85 CBFA2T3 86 87 TOP2B 88 89 MBD3 90 28 91 CTBP1 92 55 93 TOP2A 88 89 EZH2 32 COUP TFII 94 Vease tambien EditarHistona deacetilasa Inhibidor de histona deacetilasaReferencias Editar Taunton J 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referencia utiliza el parametro obsoleto coautores ayuda Enlaces externos EditarMeSH HDAC1 protein human en ingles Datos Q14914420Obtenido de https es wikipedia org w index php title Histona deacetilasa 1 amp oldid 118922450, wikipedia, wiki, leyendo, leer, libro, biblioteca,

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