CTBP1 es una proteína que posee la capacidad de unirse al extremo C-terminal de las proteínas de los adenovirus. Esta fosfoproteína es un represor transcripcional que puede jugar un importante papel durante la proliferación celular. Esta proteína, junto con el producto génico de un segundo gen estrechamente relacionado, CTBP2, pueden conformar un dímero. Ambas proteínas pueden también interaccionar con el grupo polycomb de un complejo proteico que participa en la regulación de la expresión génica durante el desarrollo. Se han descrito variantes transcripcionales de este gen por medio de splicing alternativo.[2]
Interacciones
La proteína CTBP1 ha demostrado ser capaz de interaccionar con:
Katsanis N, Fisher EM (Apr de 1998). «A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3». Genomics47 (2): 294-9. PMID 9479502. doi:10.1006/geno.1997.5115.
«Entrez Gene: CTBP1 C-terminal binding protein 1».
Oma Y, Nishimori K, Harata M (febrero de 2003). «The brain-specific actin-related protein ArpN alpha interacts with the transcriptional co-repressor CtBP». Biochem. Biophys. Res. Commun.301 (2): 521-8. PMID 12565893.
Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR (marzo de 2006). «Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis». Mol. Cell. Biol.26 (6): 2360-72. PMC 1430274. PMID 16508011. doi:10.1128/MCB.26.6.2360-2372.2006.
Chakraborty S, Senyuk V, Sitailo S, Chi Y, Nucifora G (noviembre de 2001). «Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles». J. Biol. Chem.276 (48): 44936-43. PMID 11568182. doi:10.1074/jbc.M106733200.
Izutsu K, Kurokawa M, Imai Y, Maki K, Mitani K, Hirai H (mayo de 2001). «The corepressor CtBP interacts with Evi-1 to repress transforming growth factor beta signaling». Blood97 (9): 2815-22. PMID 11313276.
Li S, Weidenfeld J, Morrisey EE (enero de 2004). «Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions». Mol. Cell. Biol.24 (2): 809-22. PMC 343786. PMID 14701752.
Zhang CL, McKinsey TA, Lu JR, Olson EN (enero de 2001). «Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor». J. Biol. Chem.276 (1): 35-9. PMID 11022042. doi:10.1074/jbc.M007364200.
↑ Melhuish TA, Wotton D (diciembre de 2000). «The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF». J. Biol. Chem.275 (50): 39762-6. PMID 10995736. doi:10.1074/jbc.C000416200.
Sundqvist A, Sollerbrant K, Svensson C (junio de 1998). «The carboxy-terminal region of adenovirus E1A activates transcription through targeting of a C-terminal binding protein-histone deacetylase complex». FEBS Lett.429 (2): 183-8. PMID 9650586.
Koipally J, Georgopoulos K (junio de 2000). «Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity». J. Biol. Chem.275 (26): 19594-602. PMID 10766745. doi:10.1074/jbc.M000254200.
Perdomo J, Crossley M (diciembre de 2002). «The Ikaros family protein Eos associates with C-terminal-binding protein corepressors». Eur. J. Biochem.269 (23): 5885-92. PMID 12444977.
Mirnezami AH, Campbell SJ, Darley M, Primrose JN, Johnson PW, Blaydes JP (julio de 2003). «Hdm2 recruits a hypoxia-sensitive corepressor to negatively regulate p53-dependent transcription». Curr. Biol.13 (14): 1234-9. PMID 12867035.
Xia ZB, Anderson M, Diaz MO, Zeleznik-Le NJ (julio de 2003). «MLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein». Proc. Natl. Acad. Sci. U.S.A.100 (14): 8342-7. PMC 166231. PMID 12829790. doi:10.1073/pnas.1436338100.
Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, Khochbin S, Jalaguier S, Cavaillès V (2004). «Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition». Nucleic Acids Res.32 (6): 1957-66. PMC 390375. PMID 15060175. doi:10.1093/nar/gkh524.
Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG (marzo de 2008). «TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints». Mol. Cell29 (6): 755-66. PMC 2364611. PMID 18374649. doi:10.1016/j.molcel.2008.01.020.
Alpatov R, Munguba GC, Caton P, Joo JH, Shi Y, Shi Y, Hunt ME, Sugrue SP (diciembre de 2004). «Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene». Mol. Cell. Biol.24 (23): 10223-35. PMC 529029. PMID 15542832. doi:10.1128/MCB.24.23.10223-10235.2004.
Li S, Chen PL, Subramanian T, Chinnadurai G, Tomlinson G, Osborne CK, Sharp ZD, Lee WH (abril de 1999). «Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage». J. Biol. Chem.274 (16): 11334-8. PMID 10196224.
Schaeper U, Subramanian T, Lim L, Boyd JM, Chinnadurai G (abril de 1998). «Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif». J. Biol. Chem.273 (15): 8549-52. PMID 9535825.
Datos:Q5014533
Agosto 17, 2022
ctbp1, proteína, unión, extremo, terminal, proteína, codificada, humanos, proteína, unión, extremo, terminalestructura, tridimensional, proteína, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsb, lista, códigos, pdb1hkuidentificadoressímbolos, hgnc, 24. La proteina 1 de union al extremo C terminal CTBP1 es una proteina codificada en humanos por el gen CTBP1 1 Proteina 1 de union al extremo C terminalEstructura tridimensional de la proteina CTBP1 Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB1hkuIdentificadoresSimbolosCTBP1 HGNC 2494 BARS MGC104684IdentificadoresexternosOMIM 602618EBI CTBP1GeneCards Gen CTBP1UniProt CTBP1LocusCr 4 p16 3 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez1487UniProtQ13363 n aRefSeq ARNm NP 001012632 n avte editar datos en Wikidata CTBP1 es una proteina que posee la capacidad de unirse al extremo C terminal de las proteinas de los adenovirus Esta fosfoproteina es un represor transcripcional que puede jugar un importante papel durante la proliferacion celular Esta proteina junto con el producto genico de un segundo gen estrechamente relacionado CTBP2 pueden conformar un dimero Ambas proteinas pueden tambien interaccionar con el grupo polycomb de un complejo proteico que participa en la regulacion de la expresion genica durante el desarrollo Se han descrito variantes transcripcionales de este gen por medio de splicing alternativo 2 Interacciones EditarLa proteina CTBP1 ha demostrado ser capaz de interaccionar con ACTL6B 3 ARF 4 EVI1 5 6 FOXP2 7 HDAC1 8 9 10 IKZF1 11 IKZF4 12 Mdm2 13 MLL 14 NRIP1 15 16 Pinina 17 RBBP8 18 19 TGIF1 9 Referencias Editar Katsanis N Fisher EM Apr de 1998 A novel C terminal binding protein CTBP2 is closely related to CTBP1 an adenovirus E1A binding protein and maps to human chromosome 21q21 3 Genomics 47 2 294 9 PMID 9479502 doi 10 1006 geno 1997 5115 Entrez Gene CTBP1 C terminal binding protein 1 Oma Y Nishimori K Harata M febrero de 2003 The brain specific actin related protein ArpN alpha interacts with the transcriptional co repressor CtBP Biochem Biophys Res Commun 301 2 521 8 PMID 12565893 Paliwal S Pande S Kovi RC Sharpless NE Bardeesy N Grossman SR marzo de 2006 Targeting of C terminal binding protein CtBP by ARF results in p53 independent apoptosis Mol Cell Biol 26 6 2360 72 PMC 1430274 PMID 16508011 doi 10 1128 MCB 26 6 2360 2372 2006 Chakraborty S Senyuk V Sitailo S Chi Y Nucifora G noviembre de 2001 Interaction of EVI1 with cAMP responsive element binding protein binding protein CBP and p300 CBP associated factor P CAF results in reversible acetylation of EVI1 and in co localization in nuclear speckles J Biol Chem 276 48 44936 43 PMID 11568182 doi 10 1074 jbc M106733200 Izutsu K Kurokawa M Imai Y Maki K Mitani K Hirai H mayo de 2001 The corepressor CtBP interacts with Evi 1 to repress transforming growth factor beta signaling Blood 97 9 2815 22 PMID 11313276 Li S Weidenfeld J Morrisey EE enero de 2004 Transcriptional and DNA binding activity of the Foxp1 2 4 family is modulated by heterotypic and homotypic protein interactions Mol Cell Biol 24 2 809 22 PMC 343786 PMID 14701752 Zhang CL McKinsey TA Lu JR Olson EN enero de 2001 Association of COOH terminal binding protein CtBP and MEF2 interacting transcription repressor MITR contributes to transcriptional repression of the MEF2 transcription factor J Biol Chem 276 1 35 9 PMID 11022042 doi 10 1074 jbc M007364200 a b Melhuish TA Wotton D diciembre de 2000 The interaction of the carboxyl terminus binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF J Biol Chem 275 50 39762 6 PMID 10995736 doi 10 1074 jbc C000416200 Sundqvist A Sollerbrant K Svensson C junio de 1998 The carboxy terminal region of adenovirus E1A activates transcription through targeting of a C terminal binding protein histone deacetylase complex FEBS Lett 429 2 183 8 PMID 9650586 Koipally J Georgopoulos K junio de 2000 Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity J Biol Chem 275 26 19594 602 PMID 10766745 doi 10 1074 jbc M000254200 Perdomo J Crossley M diciembre de 2002 The Ikaros family protein Eos associates with C terminal binding protein corepressors Eur J Biochem 269 23 5885 92 PMID 12444977 Mirnezami AH Campbell SJ Darley M Primrose JN Johnson PW Blaydes JP julio de 2003 Hdm2 recruits a hypoxia sensitive corepressor to negatively regulate p53 dependent transcription Curr Biol 13 14 1234 9 PMID 12867035 Xia ZB Anderson M Diaz MO Zeleznik Le NJ julio de 2003 MLL repression domain interacts with histone deacetylases the polycomb group proteins HPC2 and BMI 1 and the corepressor C terminal binding protein Proc Natl Acad Sci U S A 100 14 8342 7 PMC 166231 PMID 12829790 doi 10 1073 pnas 1436338100 Castet A Boulahtouf A Versini G Bonnet S Augereau P Vignon F Khochbin S Jalaguier S Cavailles V 2004 Multiple domains of the Receptor Interacting Protein 140 contribute to transcription inhibition Nucleic Acids Res 32 6 1957 66 PMC 390375 PMID 15060175 doi 10 1093 nar gkh524 Perissi V Scafoglio C Zhang J Ohgi KA Rose DW Glass CK Rosenfeld MG marzo de 2008 TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR SMRT transcriptional repression checkpoints Mol Cell 29 6 755 66 PMC 2364611 PMID 18374649 doi 10 1016 j molcel 2008 01 020 Alpatov R Munguba GC Caton P Joo JH Shi Y Shi Y Hunt ME Sugrue SP diciembre de 2004 Nuclear speckle associated protein Pnn DRS binds to the transcriptional corepressor CtBP and relieves CtBP mediated repression of the E cadherin gene Mol Cell Biol 24 23 10223 35 PMC 529029 PMID 15542832 doi 10 1128 MCB 24 23 10223 10235 2004 Li S Chen PL Subramanian T Chinnadurai G Tomlinson G Osborne CK Sharp ZD Lee WH abril de 1999 Binding of CtIP to the BRCT repeats of BRCA1 involved in the transcription regulation of p21 is disrupted upon DNA damage J Biol Chem 274 16 11334 8 PMID 10196224 Schaeper U Subramanian T Lim L Boyd JM Chinnadurai G abril de 1998 Interaction between a cellular protein that binds to the C terminal region of adenovirus E1A CtBP and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif J Biol Chem 273 15 8549 52 PMID 9535825 Datos Q5014533 Obtenido de https es wikipedia org w index php title CTBP1 amp oldid 143032256, wikipedia, wiki, leyendo, leer, libro, biblioteca,
