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Wikipedia

C-jun

Septiembre 14, 2021

c-jun es el nombre de un gen que codifica la proteína c-Jun, la cual, tras combinarse con la proteína c-Fos, conforma el factor de transcripción AP-1. Inicialmente fue identificado como proteína p39 de unión a Fos y posteriormente fue redescubierta como el producto del gen c-jun. Su activación se produce por una doble fosforilación a través de la ruta JNK, pero también se ha descrito una función alternativa independiente de fosforilación. Se ha podido comprobar que el knockout de c-jun es letal. Sin embargo, animales transgénicos cuyo gen c-jun había sido mutado de modo que la proteína c-Jun no podía ser fosforilada (denominados c-JunAA), sí podían sobrevivir. La proteína c-Jun ha demostrado ser muy similar a una proteína del virus 17 de sarcoma aviar, la cual reconoce de un modo directo secuencias específicas del ADN para regular su expresión. El gen c-jun no posee intrones y se encuentra en una región cromosómica implicada en procesos de traslocaciones y deleciones en diversas patologías humanas.[1]​

Oncogén JUN

Estructura tridimensional de la proteína c-Jun.
Estructuras disponibles
PDB

Buscar ortólogos: PDBe, RCSB

Identificadores
Símbolos JUN (HGNC: 6204) AP1, c-Jun
Identificadores
externos
Locus Cr. 1 p32.1
Patrón de expresión de ARNm
Más información
Ortólogos
Especies
Entrez
3725 16476
Ensembl
Véase HS Véase MM
UniProt
P05412 P05627
RefSeq
(ARNm)
NM_002228 NM_010591
RefSeq
(proteína) NCBI
NP_002219 NP_034721
Ubicación (UCSC)
Cr. 1:
59.25 – 59.25 Mb 		Cr. 4:
95.05 – 95.05 Mb
PubMed (Búsqueda)
[editar datos en Wikidata]

Interacciones

La proteína c-Jun ha demostrado ser capaz de interaccionar con:

Referencias

  1. «Entrez Gene: JUN jun oncogene». 
  2. Pessah, M; Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier J M, Atfi A (mayo. de 2001). «c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity». Proc. Natl. Acad. Sci. U.S.A. (United States) 98 (11): 6198-203. ISSN 0027-8424. PMID 11371641. doi:10.1073/pnas.101579798. 
  3. Verger, A; Buisine E, Carrère S, Wintjens R, Flourens A, Coll J, Stéhelin D, Duterque-Coquillaud M (mayo. de 2001). «Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg-Jun/Fos-DNA ternary complex formation». J. Biol. Chem. (United States) 276 (20): 17181-9. ISSN 0021-9258. PMID 11278640. doi:10.1074/jbc.M010208200. 
  4. Nishitani, J; Nishinaka T, Cheng C H, Rong W, Yokoyama K K, Chiu R (Feb. de 1999). «Recruitment of the retinoblastoma protein to c-Jun enhances transcription activity mediated through the AP-1 binding site». J. Biol. Chem. (UNITED STATES) 274 (9): 5454-61. ISSN 0021-9258. PMID 10026157. 
  5. Sano, Y; Tokitou F; Dai P; Maekawa T; Yamamoto T; Ishii S (Oct. de 1998). «CBP alleviates the intramolecular inhibition of ATF-2 function». J. Biol. Chem. (UNITED STATES) 273 (44): 29098-105. ISSN 0021-9258. PMID 9786917. 
  6. Newell, C L; Deisseroth A B, Lopez-Berestein G (Jul. de 1994). «Interaction of nuclear proteins with an AP-1/CRE-like promoter sequence in the human TNF-alpha gene». J. Leukoc. Biol. (UNITED STATES) 56 (1): 27-35. ISSN 0741-5400. PMID 8027667. 
  7. Kara, C J; Liou H C, Ivashkiv L B, Glimcher L H (Apr. de 1990). «A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain». Mol. Cell. Biol. (UNITED STATES) 10 (4): 1347-57. ISSN 0270-7306. PMID 2320002. 
  8. ↑ Hai, T; Curran T (mayo. de 1991). «Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 88 (9): 3720-4. ISSN 0027-8424. PMID 1827203. 
  9. Zhong, Hongjun; Zhu Jianhua, Zhang Hao, Ding Lihua, Sun Yan, Huang Cuifen, Ye Qinong (Dec. de 2004). «COBRA1 inhibits AP-1 transcriptional activity in transfected cells». Biochem. Biophys. Res. Commun. (United States) 325 (2): 568-73. ISSN 0006-291X. PMID 15530430. doi:10.1016/j.bbrc.2004.10.079. 
  10. Hu, Yan-Fen; Li Rong (Jun. de 2002). «JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction». Genes Dev. (United States) 16 (12): 1509-17. ISSN 0890-9369. PMID 12080089. doi:10.1101/gad.995502. 
  11. Ito, T; Yamauchi M; Nishina M; Yamamichi N; Mizutani T; Ui M; Murakami M; Iba H (Jan. de 2001). «Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers». J. Biol. Chem. (United States) 276 (4): 2852-7. ISSN 0021-9258. PMID 11053448. doi:10.1074/jbc.M009633200. 
  12. ↑ Pognonec, P; Boulukos K E, Aperlo C, Fujimoto M, Ariga H, Nomoto A, Kato H (mayo. de 1997). «Cross-family interaction between the bHLHZip USF and bZip Fra1 proteins results in down-regulation of AP1 activity». Oncogene (ENGLAND) 14 (17): 2091-8. ISSN 0950-9232. PMID 9160889. doi:10.1038/sj.onc.1201046. 
  13. Glover, J N; Harrison S C (Jan. de 1995). «Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA». Nature (ENGLAND) 373 (6511): 257-61. ISSN 0028-0836. PMID 7816143. doi:10.1038/373257a0. 
  14. ↑ Yang, X; Chen Y; Gabuzda D (Sep. de 1999). «ERK MAP kinase links cytokine signals to activation of latent HIV-1 infection by stimulating a cooperative interaction of AP-1 and NF-kappaB». J. Biol. Chem. (UNITED STATES) 274 (39): 27981-8. ISSN 0021-9258. PMID 10488148. 
  15. Nomura, N; Zu Y L, Maekawa T, Tabata S, Akiyama T, Ishii S (Feb. de 1993). «Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1». J. Biol. Chem. (UNITED STATES) 268 (6): 4259-66. ISSN 0021-9258. PMID 8440710. 
  16. Finkel, T; Duc J, Fearon E R, Dang C V, Tomaselli G F (Jan. de 1993). «Detection and modulation in vivo of helix-loop-helix protein-protein interactions». J. Biol. Chem. (UNITED STATES) 268 (1): 5-8. ISSN 0021-9258. PMID 8380166. 
  17. ↑ Venugopal, R; Jaiswal A K (Dec. de 1998). «Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes». Oncogene (ENGLAND) 17 (24): 3145-56. ISSN 0950-9232. PMID 9872330. doi:10.1038/sj.onc.1202237. 
  18. Westermarck, Jukka; Weiss Carsten, Saffrich Rainer, Kast Jürgen, Musti Anna-Maria, Wessely Matthias, Ansorge Wilhelm, Séraphin Bertrand, Wilm Matthias, Valdez Benigno C, Bohmann Dirk (Feb. de 2002). «The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription». EMBO J. (England) 21 (3): 451-60. ISSN 0261-4189. PMID 11823437. 
  19. ↑ Franklin, C C; McCulloch A V, Kraft A S (Feb. de 1995). «In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB». Biochem. J. (ENGLAND). 305 ( Pt 3): 967-74. ISSN 0264-6021. PMID 7848298. 
  20. Ishitani, Tohru; Takaesu Giichi, Ninomiya-Tsuji Jun, Shibuya Hiroshi, Gaynor Richard B, Matsumoto Kunihiro (Dec. de 2003). «Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling». EMBO J. (England) 22 (23): 6277-88. ISSN 0261-4189. PMID 14633987. doi:10.1093/emboj/cdg605. 
  21. Nishitoh, H; Saitoh M; Mochida Y; Takeda K; Nakano H; Rothe M; Miyazono K; Ichijo H (Sep. de 1998). «ASK1 is essential for JNK/SAPK activation by TRAF2». Mol. Cell (UNITED STATES) 2 (3): 389-95. ISSN 1097-2765. PMID 9774977. 
  22. Dérijard, B; Hibi M, Wu I H, Barrett T, Su B, Deng T, Karin M, Davis R J (Mar. de 1994). «JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain». Cell (UNITED STATES) 76 (6): 1025-37. ISSN 0092-8674. PMID 8137421. 
  23. Yazgan, Oya; Pfarr Curt M (Aug. de 2002). «Regulation of two JunD isoforms by Jun N-terminal kinases». J. Biol. Chem. (United States) 277 (33): 29710-8. ISSN 0021-9258. PMID 12052834. doi:10.1074/jbc.M204552200. 
  24. Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. de 2001). «Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death». J. Biol. Chem. (United States) 276 (39): 36530-4. ISSN 0021-9258. PMID 11479302. doi:10.1074/jbc.M104837200. 
  25. Meyer, C F; Wang X, Chang C, Templeton D, Tan T H (Apr. de 1996). «Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation». J. Biol. Chem. (UNITED STATES) 271 (15): 8971-6. ISSN 0021-9258. PMID 8621542. 
  26. Cano, E; Hazzalin C A, Kardalinou E, Buckle R S, Mahadevan L C (Nov. de 1995). «Neither ERK nor JNK/SAPK MAP kinase subtypes are essential for histone H3/HMG-14 phosphorylation or c-fos and c-jun induction». J. Cell. Sci. (ENGLAND). 108 ( Pt 11): 3599-609. ISSN 0021-9533. PMID 8586671. 
  27. Tournier, C; Whitmarsh A J, Cavanagh J, Barrett T, Davis R J (Jul. de 1997). «Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (14): 7337-42. ISSN 0027-8424. PMID 9207092. 
  28. Lee, S K; Kim J H, Lee Y C, Cheong J, Lee J W (Apr. de 2000). «Silencing mediator of retinoic acid and thyroid hormone receptors, as a novel transcriptional corepressor molecule of activating protein-1, nuclear factor-kappaB, and serum response factor». J. Biol. Chem. (UNITED STATES) 275 (17): 12470-4. ISSN 0021-9258. PMID 10777532. 
  29. Wertz, Ingrid E; O'Rourke Karen M, Zhang Zemin, Dornan David, Arnott David, Deshaies Raymond J, Dixit Vishva M (Feb. de 2004). «Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase». Science (United States) 303 (5662): 1371-4. PMID 14739464. doi:10.1126/science.1093549. 
  30. Bianchi, Elisabetta; Denti Simona, Catena Raffaella, Rossetti Grazisa, Polo Simona, Gasparian Sona, Putignano Stella, Rogge Lars, Pardi Ruggero (mayo. de 2003). «Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity». J. Biol. Chem. (United States) 278 (22): 19682-90. ISSN 0021-9258. PMID 12615916. doi:10.1074/jbc.M212681200. 
  31. Wulf, G M; Ryo A, Wulf G G, Lee S W, Niu T, Petkova V, Lu K P (Jul. de 2001). «Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1». EMBO J. (England) 20 (13): 3459-72. ISSN 0261-4189. PMID 11432833. doi:10.1093/emboj/20.13.3459. 
  32. Zhang, Y; Feng X H, Derynck R (Aug. de 1998). «Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription». Nature (ENGLAND) 394 (6696): 909-13. ISSN 0028-0836. PMID 9732876. doi:10.1038/29814. 
  33. Verrecchia, F; Pessah M; Atfi A; Mauviel A (Sep. de 2000). «Tumor necrosis factor-alpha inhibits transforming growth factor-beta /Smad signaling in human dermal fibroblasts via AP-1 activation». J. Biol. Chem. (UNITED STATES) 275 (39): 30226-31. ISSN 0021-9258. PMID 10903323. doi:10.1074/jbc.M005310200. 
  34. Liberati, N T; Datto M B, Frederick J P, Shen X, Wong C, Rougier-Chapman E M, Wang X F (Apr. de 1999). «Smads bind directly to the Jun family of AP-1 transcription factors». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (9): 4844-9. ISSN 0027-8424. PMID 10220381. 
  35. Jung, Dong-Ju; Sung Hee-Sook, Goo Young-Wha, Lee Hyun Mi, Park Ok Ku, Jung Sung-Yun, Lim Janghoo, Kim Han-Jong, Lee Soo-Kyung, Kim Tae Sung, Lee Jae Woon, Lee Young Chul (Jul. de 2002). «Novel transcription coactivator complex containing activating signal cointegrator 1». Mol. Cell. Biol. (United States) 22 (14): 5203-11. ISSN 0270-7306. PMID 12077347. 
  36. ↑ Yamaguchi, Y; Wada T; Suzuki F; Takagi T; Hasegawa J; Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854-61. ISSN 0305-1048. PMID 9685505. 
  37. ↑ Zhang, X; Wrzeszczynska M H, Horvath C M, Darnell J E (Oct. de 1999). «Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation». Mol. Cell. Biol. (UNITED STATES) 19 (10): 7138-46. ISSN 0270-7306. PMID 10490649. 
  38. Vasanwala, Farha H; Kusam Saritha, Toney Lisa M, Dent Alexander L (Aug. de 2002). «Repression of AP-1 function: a mechanism for the regulation of Blimp-1 expression and B lymphocyte differentiation by the B cell lymphoma-6 protooncogene». J. Immunol. (United States) 169 (4): 1922-9. ISSN 0022-1767. PMID 12165517. 
  39. Na, S Y; Choi J E, Kim H J, Jhun B H, Lee Y C, Lee J W (Oct. de 1999). «Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation». J. Biol. Chem. (UNITED STATES) 274 (40): 28491-6. ISSN 0021-9258. PMID 10497212. 
  40. Sato, N; Sadar M D, Bruchovsky N, Saatcioglu F, Rennie P S, Sato S, Lange P H, Gleave M E (Jul. de 1997). «Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-Jun in the human prostate cancer cell line LNCaP». J. Biol. Chem. (UNITED STATES) 272 (28): 17485-94. ISSN 0021-9258. PMID 9211894. 
  41. Basuyaux, J P; Ferreira E, Stéhelin D, Butticè G (Oct. de 1997). «The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner». J. Biol. Chem. (UNITED STATES) 272 (42): 26188-95. ISSN 0021-9258. PMID 9334186. 
  42. Pearson, Andree G; Gray Carol W, Pearson John F, Greenwood Jeffrey M, During Matthew J, Dragunow Michael (Dec. de 2003). «ATF3 enhances c-Jun-mediated neurite sprouting». Brain Res. Mol. Brain Res. (Netherlands) 120 (1): 38-45. ISSN 0169-328X. PMID 14667575. 
  43. Chen, B P; Wolfgang C D, Hai T (Mar. de 1996). «Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10». Mol. Cell. Biol. (UNITED STATES) 16 (3): 1157-68. ISSN 0270-7306. PMID 8622660. 
  44. Moreau, A; Yotov W V, Glorieux F H, St-Arnaud R (Mar. de 1998). «Bone-specific expression of the alpha chain of the nascent polypeptide-associated complex, a coactivator potentiating c-Jun-mediated transcription». Mol. Cell. Biol. (UNITED STATES) 18 (3): 1312-21. ISSN 0270-7306. PMID 9488446. 
  45. Claret, F X; Hibi M; Dhut S; Toda T; Karin M (Oct. de 1996). «A new group of conserved coactivators that increase the specificity of AP-1 transcription factors». Nature (ENGLAND) 383 (6599): 453-7. ISSN 0028-0836. PMID 8837781. doi:10.1038/383453a0. 
  46. Ubeda, M; Vallejo M, Habener J F (Nov. de 1999). «CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins». Mol. Cell. Biol. (UNITED STATES) 19 (11): 7589-99. ISSN 0270-7306. PMID 10523647. 
  47. Jung, Dong-Ju; Na Soon-Young, Na Doe Sun, Lee Jae Woon (Jan. de 2002). «Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors». J. Biol. Chem. (United States) 277 (2): 1229-34. ISSN 0021-9258. PMID 11704680. doi:10.1074/jbc.M110417200. 
  48. Lee, S K; Anzick S L, Choi J E, Bubendorf L, Guan X Y, Jung Y K, Kallioniemi O P, Kononen J, Trent J M, Azorsa D, Jhun B H, Cheong J H, Lee Y C, Meltzer P S, Lee J W (Nov. de 1999). «A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo». J. Biol. Chem. (UNITED STATES) 274 (48): 34283-93. ISSN 0021-9258. PMID 10567404. 
  49. Lee, S K; Na S Y, Jung S Y, Choi J E, Jhun B H, Cheong J, Meltzer P S, Lee Y C, Lee J W (Jun. de 2000). «Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2». Mol. Endocrinol. (UNITED STATES) 14 (6): 915-25. ISSN 0888-8809. PMID 10847592. 
  50. Lee, S K; Kim H J, Na S Y, Kim T S, Choi H S, Im S Y, Lee J W (Jul. de 1998). «Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits». J. Biol. Chem. (UNITED STATES) 273 (27): 16651-4. ISSN 0021-9258. PMID 9642216. 
  51. Bengal, E; Ransone L, Scharfmann R, Dwarki V J, Tapscott S J, Weintraub H, Verma I M (Feb. de 1992). «Functional antagonism between c-Jun and MyoD proteins: a direct physical association». Cell (UNITED STATES) 68 (3): 507-19. ISSN 0092-8674. PMID 1310896. 
  52. ↑ Hess, J; Porte D; Munz C; Angel P (Jun. de 2001). «AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite element». J. Biol. Chem. (United States) 276 (23): 20029-38. ISSN 0021-9258. PMID 11274169. doi:10.1074/jbc.M010601200. 
  53. ↑ D'Alonzo, Richard C; Selvamurugan Nagarajan, Karsenty Gerard, Partridge Nicola C (Jan. de 2002). «Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation». J. Biol. Chem. (United States) 277 (1): 816-22. ISSN 0021-9258. PMID 11641401. doi:10.1074/jbc.M107082200. 

Véase también

Enlaces externos

  • MeSH: c-jun+Proteins (en inglés)
  • MeSH: c-jun+Genes (en inglés)
  •   Datos: Q5005943

Septiembre 14, 2021
nombre, codifica, proteína, cual, tras, combinarse, proteína, conforma, factor, transcripción, inicialmente, identificado, como, proteína, unión, posteriormente, redescubierta, como, producto, activación, produce, doble, fosforilación, través, ruta, pero, tamb. c jun es el nombre de un gen que codifica la proteina c Jun la cual tras combinarse con la proteina c Fos conforma el factor de transcripcion AP 1 Inicialmente fue identificado como proteina p39 de union a Fos y posteriormente fue redescubierta como el producto del gen c jun Su activacion se produce por una doble fosforilacion a traves de la ruta JNK pero tambien se ha descrito una funcion alternativa independiente de fosforilacion Se ha podido comprobar que el knockout de c jun es letal Sin embargo animales transgenicos cuyo gen c jun habia sido mutado de modo que la proteina c Jun no podia ser fosforilada denominados c JunAA si podian sobrevivir La proteina c Jun ha demostrado ser muy similar a una proteina del virus 17 de sarcoma aviar la cual reconoce de un modo directo secuencias especificas del ADN para regular su expresion El gen c jun no posee intrones y se encuentra en una region cromosomica implicada en procesos de traslocaciones y deleciones en diversas patologias humanas 1 Oncogen JUNEstructura tridimensional de la proteina c Jun Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB1A02 1FOS 1JNM 1JUN 1S9K 1T2KIdentificadoresSimbolosJUN HGNC 6204 AP1 c JunIdentificadoresexternosOMIM 165160HomoloGene 1679ChEMBL 4977EBI JUNGeneCards Gen JUNUniProt JUNLocusCr 1 p32 1 Ontologia genicaReferencias AmiGO QuickGOPatron de expresion de ARNmMas informacionOrtologosEspeciesHumano RatonEntrez3725 16476EnsemblVease HS Vease MMUniProtP05412 P05627RefSeq ARNm NM 002228 NM 010591RefSeq proteina NCBINP 002219 NP 034721Ubicacion UCSC Cr 1 59 25 59 25 Mb Cr 4 95 05 95 05 MbPubMed Busqueda 1 2 vte editar datos en Wikidata Indice 1 Interacciones 2 Referencias 3 Vease tambien 4 Enlaces externosInteracciones EditarLa proteina c Jun ha demostrado ser capaz de interaccionar con TGIF1 2 ERG 3 Proteina del retinoblastoma 4 CREBBP 5 ATF2 6 7 8 Cofactor de BRCA1 9 BRCA1 10 c Fos 11 12 13 14 15 16 17 NFE2L1 17 DDX21 18 NFE2L2 17 Proteina de union a TATA 19 RELA 14 MAPK8 20 21 22 23 24 25 26 27 NCOR2 28 RFWD2 29 30 PIN1 31 FOSL1 12 SMAD3 32 33 34 ASCC3 35 Factor de transcripcion II B 19 CSNK2A2 36 CSNK2A1 36 STAT1 37 BCL6 38 BCL3 39 Receptor androgenico 40 STAT3 37 ETS2 41 ATF3 42 43 8 NACA 44 COPS5 45 DDIT3 46 RBM39 47 NCOA1 48 49 50 MyoD 51 RUNX2 52 53 RUNX1 52 53 Referencias Editar Entrez Gene JUN jun oncogene Pessah M Prunier C Marais J Ferrand N Mazars A Lallemand F Gauthier J M Atfi A mayo de 2001 c Jun interacts with the corepressor TG interacting factor TGIF to suppress Smad2 transcriptional activity Proc Natl Acad Sci U S A United States 98 11 6198 203 ISSN 0027 8424 PMID 11371641 doi 10 1073 pnas 101579798 La referencia utiliza el parametro obsoleto coautores ayuda Verger A Buisine E Carrere S Wintjens R Flourens A Coll J Stehelin D Duterque Coquillaud M mayo de 2001 Identification of amino acid residues in the ETS transcription factor Erg that mediate Erg Jun Fos DNA ternary complex formation J Biol Chem United States 276 20 17181 9 ISSN 0021 9258 PMID 11278640 doi 10 1074 jbc M010208200 La referencia utiliza el parametro obsoleto coautores ayuda Nishitani J Nishinaka T Cheng C H Rong W Yokoyama K K Chiu R Feb de 1999 Recruitment of the retinoblastoma protein to c Jun enhances transcription activity mediated through the AP 1 binding site J Biol Chem UNITED STATES 274 9 5454 61 ISSN 0021 9258 PMID 10026157 La referencia utiliza el parametro obsoleto coautores ayuda Sano Y Tokitou F Dai P Maekawa T Yamamoto T Ishii S Oct de 1998 CBP alleviates the intramolecular inhibition of ATF 2 function J Biol Chem UNITED STATES 273 44 29098 105 ISSN 0021 9258 PMID 9786917 Newell C L Deisseroth A B Lopez Berestein G Jul de 1994 Interaction of nuclear proteins with an AP 1 CRE like promoter sequence in the human TNF alpha gene J Leukoc Biol UNITED STATES 56 1 27 35 ISSN 0741 5400 PMID 8027667 La referencia utiliza el parametro obsoleto coautores ayuda Kara C J Liou H C Ivashkiv L B Glimcher L H Apr de 1990 A cDNA for a human cyclic AMP response element binding protein which is distinct from CREB and expressed preferentially in brain Mol Cell Biol UNITED STATES 10 4 1347 57 ISSN 0270 7306 PMID 2320002 La referencia utiliza el parametro obsoleto coautores ayuda a b Hai T Curran T mayo de 1991 Cross family dimerization of transcription factors Fos Jun and ATF CREB alters DNA binding specificity Proc Natl Acad Sci U S A UNITED STATES 88 9 3720 4 ISSN 0027 8424 PMID 1827203 Zhong Hongjun Zhu Jianhua Zhang Hao Ding Lihua Sun Yan Huang Cuifen Ye Qinong Dec de 2004 COBRA1 inhibits AP 1 transcriptional activity in transfected cells Biochem Biophys Res Commun United States 325 2 568 73 ISSN 0006 291X PMID 15530430 doi 10 1016 j bbrc 2004 10 079 La referencia utiliza el parametro obsoleto coautores ayuda Hu Yan Fen Li Rong Jun de 2002 JunB potentiates function of BRCA1 activation domain 1 AD1 through a coiled coil mediated interaction Genes Dev United States 16 12 1509 17 ISSN 0890 9369 PMID 12080089 doi 10 1101 gad 995502 Ito T Yamauchi M Nishina M Yamamichi N Mizutani T Ui M Murakami M Iba H Jan de 2001 Identification of SWI SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos Jun dimers J Biol Chem United States 276 4 2852 7 ISSN 0021 9258 PMID 11053448 doi 10 1074 jbc M009633200 a b Pognonec P Boulukos K E Aperlo C Fujimoto M Ariga H Nomoto A Kato H mayo de 1997 Cross family interaction between the bHLHZip USF and bZip Fra1 proteins results in down regulation of AP1 activity Oncogene ENGLAND 14 17 2091 8 ISSN 0950 9232 PMID 9160889 doi 10 1038 sj onc 1201046 La referencia utiliza el parametro obsoleto coautores ayuda Glover J N Harrison S C Jan de 1995 Crystal structure of the heterodimeric bZIP 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c jun Genes en ingles Datos Q5005943Obtenido de https es wikipedia org w index php title C jun amp oldid 132913940, wikipedia, wiki, leyendo, leer, libro, biblioteca,

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