El factor de unión a repeticiones teloméricas 1, o TERF1 por sus siglas en inglés: Telomeric repeat binding factor (NIMA-interacting) 1, es un gen humano.[1]
Este gen codifica una proteína específica de telómeros que es un componente de las nucleoproteínas teloméricas. Esta proteína está presente en los telómeros a lo largo de todo el ciclo celular, funcionando como inhibidor de la telomerasa, actuando en cis para limitar la elongación de la región final del cromosoma. La estructura de la proteína contiene en posición C-terminal un motivo Myb, un dominio de dimerización próximo a su extremo N-terminal, teniendo este último cadenas laterales de aminoácidos de tipo acídico. El splicing alternativo de este gen da lugar a dos productos.[1]
Zhong Z, Shiue L, Kaplan S, de Lange T (1992). «A mammalian factor that binds telomeric TTAGGG repeats in vitro.». Mol. Cell. Biol.12 (11): 4834-43. PMID 1406665.
Chong L, van Steensel B, Broccoli D, et al. (1996). «A human telomeric protein.». Science270 (5242): 1663-7. PMID 7502076.
Lu KP, Hanes SD, Hunter T (1996). «A human peptidyl-prolyl isomerase essential for regulation of mitosis.». Nature380 (6574): 544-7. PMID 8606777. doi:10.1038/380544a0.
Bilaud T, Koering CE, Binet-Brasselet E, et al. (1996). «The telobox, a Myb-related telomeric DNA binding motif found in proteins from yeast, plants and human.». Nucleic Acids Res.24 (7): 1294-303. PMID 8614633.
Broccoli D, Chong L, Oelmann S, et al. (1997). «Comparison of the human and mouse genes encoding the telomeric protein, TRF1: chromosomal localization, expression and conserved protein domains.». Hum. Mol. Genet.6 (1): 69-76. PMID 9002672.
Bianchi A, Smith S, Chong L, et al. (1997). «TRF1 is a dimer and bends telomeric DNA.». EMBO J.16 (7): 1785-94. PMID 9130722. doi:10.1093/emboj/16.7.1785.
Broccoli D, Smogorzewska A, Chong L, de Lange T (1997). «Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2.». Nat. Genet.17 (2): 231-5. PMID 9326950. doi:10.1038/ng1097-231.
Shen M, Haggblom C, Vogt M, et al. (1998). «Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis.». Proc. Natl. Acad. Sci. U.S.A.94 (25): 13618-23. PMID 9391075.
Nosaka K, Kawahara M, Masuda M, et al. (1998). «Association of nucleoside diphosphate kinase nm23-H2 with human telomeres.». Biochem. Biophys. Res. Commun.243 (2): 342-8. PMID 9480811. doi:10.1006/bbrc.1997.8097.
Nishikawa T, Nagadoi A, Yoshimura S, et al. (1998). «Solution structure of the DNA-binding domain of human telomeric protein, hTRF1.». Structure6 (8): 1057-65. PMID 9739097.
Smith S, Giriat I, Schmitt A, de Lange T (1998). «Tankyrase, a poly(ADP-ribose) polymerase at human telomeres.». Science282 (5393): 1484-7. PMID 9822378.
Kim SH, Kaminker P, Campisi J (1999). «TIN2, a new regulator of telomere length in human cells.». Nat. Genet.23 (4): 405-12. PMID 10581025. doi:10.1038/70508.
Smogorzewska A, van Steensel B, Bianchi A, et al. (2000). «Control of human telomere length by TRF1 and TRF2.». Mol. Cell. Biol.20 (5): 1659-68. PMID 10669743.
Wu G, Lee WH, Chen PL (2000). «NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres.». J. Biol. Chem.275 (39): 30618-22. PMID 10913111. doi:10.1074/jbc.C000390200.
Chi NW, Lodish HF (2001). «Tankyrase is a golgi-associated mitogen-activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles.». J. Biol. Chem.275 (49): 38437-44. PMID 10988299. doi:10.1074/jbc.M007635200.
Kishi S, Wulf G, Nakamura M, Lu KP (2001). «Telomeric protein Pin2/TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down-regulated in human breast tumors.». Oncogene20 (12): 1497-508. PMID 11313893. doi:10.1038/sj.onc.1204229.
Kishi S, Zhou XZ, Ziv Y, et al. (2001). «Telomeric protein Pin2/TRF1 as an important ATM target in response to double strand DNA breaks.». J. Biol. Chem.276 (31): 29282-91. PMID 11375976. doi:10.1074/jbc.M011534200.
Fairall L, Chapman L, Moss H, et al. (2001). «Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2.». Mol. Cell8 (2): 351-61. PMID 11545737.
Zhou XZ, Lu KP (2001). «The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor.». Cell107 (3): 347-59. PMID 11701125.
Nishikawa T, Okamura H, Nagadoi A, et al. (2002). «Solution structure of a telomeric DNA complex of human TRF1.». Structure9 (12): 1237-51. PMID 11738049.
Datos:Q18031948
Agosto 17, 2021
terf1, factor, unión, repeticiones, teloméricas, siglas, inglés, telomeric, repeat, binding, factor, nima, interacting, humano, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsb, lista, códigos, pdb1ba5, 1h6o, 1ity, 1iv6, 1w0t, 3bqo, 3l82identificadores. El factor de union a repeticiones telomericas 1 o TERF1 por sus siglas en ingles Telomeric repeat binding factor NIMA interacting 1 es un gen humano 1 TERF1Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82IdentificadoresIdentificadoresexternosOMIM 600951MGI 109634HomoloGene 7570EBI TERF1GeneCards Gen TERF1UniProt TERF1LocusCr 8 q13 Ontologia genicaFuncion molecular Union a ADN Union a ADN telomerico de cadena doble Union dimericaComponente celular Cromosoma en Telomero Nucleo CromosomaProceso biologico Mantenimiento de telomeros via telomerasa Ciclo celular Mitosis Regulacion de la transcripcion Division celularReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez7013 21749EnsemblVease HS Vease MMUniProtP54274 P70371RefSeq ARNm NM 003218 NM 009352RefSeq proteina NCBINP 003209 NP 033378Ubicacion UCSC Cr 8 73 92 73 96 Mb Cr 1 15 81 15 84 MbPubMed Busqueda 1 2 vte editar datos en Wikidata Este gen codifica una proteina especifica de telomeros que es un componente de las nucleoproteinas telomericas Esta proteina esta presente en los telomeros a lo largo de todo el ciclo celular funcionando como inhibidor de la telomerasa actuando en cis para limitar la elongacion de la region final del cromosoma La estructura de la proteina contiene en posicion C terminal un motivo Myb un dominio de dimerizacion proximo a su extremo N terminal teniendo este ultimo cadenas laterales de aminoacidos de tipo acidico El splicing alternativo de este gen da lugar a dos productos 1 Referencias Editar a b Entrez Gene TERF1 telomeric repeat binding factor NIMA interacting 1 Bibliografia EditarZhong Z Shiue L Kaplan S de Lange T 1992 A mammalian factor that binds telomeric TTAGGG repeats in vitro Mol Cell Biol 12 11 4834 43 PMID 1406665 Chong L van Steensel B Broccoli D et al 1996 A human telomeric protein Science 270 5242 1663 7 PMID 7502076 Lu KP Hanes SD Hunter T 1996 A human peptidyl prolyl isomerase essential for regulation of mitosis Nature 380 6574 544 7 PMID 8606777 doi 10 1038 380544a0 Bilaud T Koering CE Binet Brasselet E et al 1996 The telobox a Myb related telomeric DNA binding motif found in proteins from yeast plants and human Nucleic Acids Res 24 7 1294 303 PMID 8614633 Broccoli D Chong L Oelmann S et al 1997 Comparison of the human and mouse genes encoding the telomeric protein TRF1 chromosomal localization expression and conserved protein domains Hum Mol Genet 6 1 69 76 PMID 9002672 Bianchi A Smith S Chong L et al 1997 TRF1 is a dimer and bends telomeric DNA EMBO J 16 7 1785 94 PMID 9130722 doi 10 1093 emboj 16 7 1785 Broccoli D Smogorzewska A Chong L de Lange T 1997 Human telomeres contain two distinct Myb related proteins TRF1 and TRF2 Nat Genet 17 2 231 5 PMID 9326950 doi 10 1038 ng1097 231 Shen M Haggblom C Vogt M et al 1998 Characterization and cell cycle regulation of the related human telomeric proteins Pin2 and TRF1 suggest a role in mitosis Proc Natl Acad Sci U S A 94 25 13618 23 PMID 9391075 Nosaka K Kawahara M Masuda M et al 1998 Association of nucleoside diphosphate kinase nm23 H2 with human telomeres Biochem Biophys Res Commun 243 2 342 8 PMID 9480811 doi 10 1006 bbrc 1997 8097 Nishikawa T Nagadoi A Yoshimura S et al 1998 Solution structure of the DNA binding domain of human telomeric protein hTRF1 Structure 6 8 1057 65 PMID 9739097 Smith S Giriat I Schmitt A de Lange T 1998 Tankyrase a poly ADP ribose polymerase at human telomeres Science 282 5393 1484 7 PMID 9822378 Kim SH Kaminker P Campisi J 1999 TIN2 a new regulator of telomere length in human cells Nat Genet 23 4 405 12 PMID 10581025 doi 10 1038 70508 Smogorzewska A van Steensel B Bianchi A et al 2000 Control of human telomere length by TRF1 and TRF2 Mol Cell Biol 20 5 1659 68 PMID 10669743 Wu G Lee WH Chen PL 2000 NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S G2 phases in immortalized telomerase negative cells Implication of NBS1 in alternative lengthening of telomeres J Biol Chem 275 39 30618 22 PMID 10913111 doi 10 1074 jbc C000390200 Chi NW Lodish HF 2001 Tankyrase is a golgi associated mitogen activated protein kinase substrate that interacts with IRAP in GLUT4 vesicles J Biol Chem 275 49 38437 44 PMID 10988299 doi 10 1074 jbc M007635200 Kishi S Wulf G Nakamura M Lu KP 2001 Telomeric protein Pin2 TRF1 induces mitotic entry and apoptosis in cells with short telomeres and is down regulated in human breast tumors Oncogene 20 12 1497 508 PMID 11313893 doi 10 1038 sj onc 1204229 Kishi S Zhou XZ Ziv Y et al 2001 Telomeric protein Pin2 TRF1 as an important ATM target in response to double strand DNA breaks J Biol Chem 276 31 29282 91 PMID 11375976 doi 10 1074 jbc M011534200 Fairall L Chapman L Moss H et al 2001 Structure of the TRFH dimerization domain of the human telomeric proteins TRF1 and TRF2 Mol Cell 8 2 351 61 PMID 11545737 Zhou XZ Lu KP 2001 The Pin2 TRF1 interacting protein PinX1 is a potent telomerase inhibitor Cell 107 3 347 59 PMID 11701125 Nishikawa T Okamura H Nagadoi A et al 2002 Solution structure of a telomeric DNA complex of human TRF1 Structure 9 12 1237 51 PMID 11738049 Datos Q18031948Obtenido de https es wikipedia org w index php title TERF1 amp oldid 131646917, wikipedia, wiki, leyendo, leer, libro, biblioteca,
