RBPJ,[4] también conocida como CBF1, es un homólogo del gen de Drosophila Su(H) (supresor de calvicie). Es clásicamente usado como una región promotora para demostrar la existencia de la ruta de señalización Notch.[5]
Interacciones
La proteína RBPJ ha demostrado ser capaz de interaccionar con:
Amakawa R, Jing W, Ozawa K, Matsunami N, Hamaguchi Y, Matsuda F, Kawaichi M, Honjo T (Oct de 1993). «Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue». Genomics17 (2): 306-15. PMID 8406481. doi:10.1006/geno.1993.1326.
Tang X, Saito-Ohara F, Song J, Koga C, Ugai H, Murakami H, Ikeuchi T, Yokoyama KK (Nov de 1997). «Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization». Jpn J Hum Genet42 (2): 337-41. PMID 9290259.
«Entrez Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region».
. Archivado desde el original el 12 de mayo de 2011.
Hsieh JJ, Henkel T, Salmon P, Robey E, Peterson MG, Hayward SD (1996). «Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2.». Molecular and Cellular Biology16 (3): 952-959. PMID 8622698.
Kurooka, H; Honjo T (Jun. de 2000). «Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5». J. Biol. Chem. (UNITED STATES) 275 (22): 17211-20. ISSN 0021-9258. PMID 10747963. doi:10.1074/jbc.M000909200.
Beatus, P; Lundkvist J; Oberg C; Pedersen K; Lendahl U (Jun. de 2001). «The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity». Mech. Dev. (Ireland) 104 (1-2): 3-20. ISSN 0925-4773. PMID 11404076.
Zhou, S; Hayward S D (Sep. de 2001). «Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex». Mol. Cell. Biol. (United States) 21 (18): 6222-32. ISSN 0270-7306. PMID 11509665.
↑ Zhou, S; Fujimuro M, Hsieh J J, Chen L, Hayward S D (Feb. de 2000). «A role for SKIP in EBNA2 activation of CBF1-repressed promoters». J. Virol. (UNITED STATES) 74 (4): 1939-47. ISSN 0022-538X. PMID 10644367.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Zhou, S; Fujimuro M, Hsieh J J, Chen L, Miyamoto A, Weinmaster G, Hayward S D (Apr. de 2000). «SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function». Mol. Cell. Biol. (UNITED STATES) 20 (7): 2400-10. ISSN 0270-7306. PMID 10713164.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Nam, Yunsun; Weng Andrew P, Aster Jon C, Blacklow Stephen C (Jun. de 2003). «Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex». J. Biol. Chem. (United States) 278 (23): 21232-9. ISSN 0021-9258. PMID 12644465. doi:10.1074/jbc.M301567200.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Aster, J C; Robertson E S, Hasserjian R P, Turner J R, Kieff E, Sklar J (Apr. de 1997). «Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription». J. Biol. Chem. (UNITED STATES) 272 (17): 11336-43. ISSN 0021-9258. PMID 9111040.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Hsieh, J J; Zhou S, Chen L, Young D B, Hayward S D (Jan. de 1999). «CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (1): 23-8. ISSN 0027-8424. PMID 9874765.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
rbpj, proteína, recombinante, unión, supresora, calvicie, proteína, codificada, humanos, proteína, unión, tataestructura, tridimensional, proteína, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsb, lista, códigos, pdb2f8xidentificadoressímbolos, hgnc, . La proteina recombinante de union supresora de calvicie RBPJ es una proteina codificada en humanos por el gen RBPJ 1 2 3 Proteina de union a TATAEstructura tridimensional de la proteina RBPJ Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB2f8xIdentificadoresSimbolosRBPJ HGNC 5724 CBF1 IGKJRB IGKJRB1 KBF2 MGC61669 RBP J RBPJK RBPSUH SUH cslIdentificadoresexternosOMIM 147183EBI RBPJGeneCards Gen RBPJUniProt RBPJLocusCr 4 p15 2 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez3516UniProtQ06330 n aRefSeq ARNm NP 005340 n avte editar datos en Wikidata RBPJ 4 tambien conocida como CBF1 es un homologo del gen de Drosophila Su H supresor de calvicie Es clasicamente usado como una region promotora para demostrar la existencia de la ruta de senalizacion Notch 5 Interacciones EditarLa proteina RBPJ ha demostrado ser capaz de interaccionar con PCAF 6 NCOR2 7 8 SNW1 9 10 NOTCH1 11 12 SND1 9 13 Referencias Editar Amakawa R Jing W Ozawa K Matsunami N Hamaguchi Y Matsuda F Kawaichi M Honjo T Oct de 1993 Human Jk recombination signal binding protein gene IGKJRB comparison with its mouse homologue Genomics 17 2 306 15 PMID 8406481 doi 10 1006 geno 1993 1326 Tang X Saito Ohara F Song J Koga C Ugai H Murakami H Ikeuchi T Yokoyama KK Nov de 1997 Assignment of the human gene for KBF2 RBP Jk to chromosome 9p12 13 and 9q13 by fluorescence in situ hybridization Jpn J Hum Genet 42 2 337 41 PMID 9290259 Entrez Gene RBPJ recombination signal binding protein for immunoglobulin kappa J region Human Genome Organization RBPJ Report Archivado desde el original el 12 de mayo de 2011 Hsieh JJ Henkel T Salmon P Robey E Peterson MG Hayward SD 1996 Truncated mammalian Notch1 activates CBF1 RBPJk repressed genes by a mechanism resembling that of Epstein Barr virus EBNA2 Molecular and Cellular Biology 16 3 952 959 PMID 8622698 Kurooka H Honjo T Jun de 2000 Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5 J Biol Chem UNITED STATES 275 22 17211 20 ISSN 0021 9258 PMID 10747963 doi 10 1074 jbc M000909200 Beatus P Lundkvist J Oberg C Pedersen K Lendahl U Jun de 2001 The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity Mech Dev Ireland 104 1 2 3 20 ISSN 0925 4773 PMID 11404076 Zhou S Hayward S D Sep de 2001 Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex Mol Cell Biol United States 21 18 6222 32 ISSN 0270 7306 PMID 11509665 a b Zhou S Fujimuro M Hsieh J J Chen L Hayward S D Feb de 2000 A role for SKIP in EBNA2 activation of CBF1 repressed promoters J Virol UNITED STATES 74 4 1939 47 ISSN 0022 538X PMID 10644367 La referencia utiliza el parametro obsoleto coautores ayuda Zhou S Fujimuro M Hsieh J J Chen L Miyamoto A Weinmaster G Hayward S D Apr de 2000 SKIP a CBF1 associated protein interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function Mol Cell Biol UNITED STATES 20 7 2400 10 ISSN 0270 7306 PMID 10713164 La referencia utiliza el parametro obsoleto coautores ayuda Nam Yunsun Weng Andrew P Aster Jon C Blacklow Stephen C Jun de 2003 Structural requirements for assembly of the CSL intracellular Notch1 Mastermind like 1 transcriptional activation complex J Biol Chem United States 278 23 21232 9 ISSN 0021 9258 PMID 12644465 doi 10 1074 jbc M301567200 La referencia utiliza el parametro obsoleto coautores ayuda Aster J C Robertson E S Hasserjian R P Turner J R Kieff E Sklar J Apr de 1997 Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP Jkappa or nuclear localization sequences retain the ability to associate with RBP Jkappa and activate transcription J Biol Chem UNITED STATES 272 17 11336 43 ISSN 0021 9258 PMID 9111040 La referencia utiliza el parametro obsoleto coautores ayuda Hsieh J J Zhou S Chen L Young D B Hayward S D Jan de 1999 CIR a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex Proc Natl Acad Sci U S A UNITED STATES 96 1 23 8 ISSN 0027 8424 PMID 9874765 La referencia utiliza el parametro obsoleto coautores ayuda Enlaces externos EditarMeSH RBPJ protein human en ingles Datos Q18027737 Obtenido de https es wikipedia org w index php title RBPJ amp oldid 142387848, wikipedia, wiki, leyendo, leer, libro, biblioteca,
