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Wikipedia

Proteína del retinoblastoma-like 2

Agosto 17, 2021

La proteína del retinoblastoma-like 2 (p130) es un factor de transcripción codificado en humanos por el gen rbl2.[1]​[2]​ Esta proteína pertenece a la familia de proteínas bolsillo.

Proteína del retinoblastoma-like 2
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos RBL2 (HGNC: 9894) FLJ26459; P130; Rb2
Identificadores
externos
Locus Cr. 16 q12.2
Ortólogos
Especies
Entrez
5934
UniProt
Q08999 n/a
RefSeq
(ARNm)
NP_005602 n/a
[editar datos en Wikidata]

Interacciones

La proteína del retinoblastoma-like 2 ha demostrado ser capaz de interaccionar con:

Véase también

Referencias

  1. Mayol X, Grana X, Baldi A, Sang N, Hu Q, Giordano A (Sep de 1993). «Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain». Oncogene 8 (9): 2561-6. PMID 8361765. 
  2. Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A (Jul de 1996). «Genomic structure of the human retinoblastoma-related Rb2/p130 gene». Proc Natl Acad Sci U S A 93 (10): 4629-32. PMC 39329. PMID 8643454. 
  3. Ferreira, R; Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D (Sep. de 1998). «The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 95 (18): 10493-8. ISSN 0027-8424. PMID 9724731. 
  4. Bouzahzah, B; Fu M, Iavarone A, Factor V M, Thorgeirsson S S, Pestell R G (Aug. de 2000). «Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo». Cancer Res. (UNITED STATES) 60 (16): 4531-7. ISSN 0008-5472. PMID 10969803. 
  5. Wang, S; Ghosh R N, Chellappan S P (Dec. de 1998). «Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation». Mol. Cell. Biol. (UNITED STATES) 18 (12): 7487-98. ISSN 0270-7306. PMID 9819434. 
  6. Meloni, A R; Smith E J, Nevins J R (Aug. de 1999). «A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor». Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 96 (17): 9574-9. ISSN 0027-8424. PMID 10449734. 
  7. Fusco, C; Reymond A, Zervos A S (Aug. de 1998). «Molecular cloning and characterization of a novel retinoblastoma-binding protein». Genomics (UNITED STATES) 51 (3): 351-8. ISSN 0888-7543. PMID 9721205. doi:10.1006/geno.1998.5368. 
  8. ↑ Shanahan, F; Seghezzi W; Parry D; Mahony D; Lees E (Feb. de 1999). «Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest». Mol. Cell. Biol. (UNITED STATES) 19 (2): 1460-9. ISSN 0270-7306. PMID 9891079. 
  9. Li, Y; Graham C, Lacy S, Duncan A M, Whyte P (Dec. de 1993). «The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E». Genes Dev. (UNITED STATES) 7 (12A): 2366-77. ISSN 0890-9369. PMID 8253383. 
  10. Wang, S; Nath N; Adlam M; Chellappan S (Jun. de 1999). «Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function». Oncogene (ENGLAND) 18 (23): 3501-10. ISSN 0950-9232. PMID 10376528. doi:10.1038/sj.onc.1202684. 
  11. Lacy, S; Whyte P (mayo. de 1997). «Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes». Oncogene (ENGLAND) 14 (20): 2395-406. ISSN 0950-9232. PMID 9188854. doi:10.1038/sj.onc.1201085. 
  12. Sutcliffe, J E; Cairns C A, McLees A, Allison S J, Tosh K, White R J (Jun. de 1999). «RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130». Mol. Cell. Biol. (UNITED STATES) 19 (6): 4255-61. ISSN 0270-7306. PMID 10330166. 
  13. Fan, S; Yuan R, Ma Y X, Xiong J, Meng Q, Erdos M, Zhao J N, Goldberg I D, Pestell R G, Rosen E M (Aug. de 2001). «Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding». Oncogene (England) 20 (35): 4827-41. ISSN 0950-9232. PMID 11521194. doi:10.1038/sj.onc.1204666. 

Enlaces externos

  • MeSH: RBL2+protein,+human (en inglés)
  •   Datos: Q18031061

Agosto 17, 2021
proteína, retinoblastoma, like, proteína, retinoblastoma, like, p130, factor, transcripción, codificado, humanos, rbl2, esta, proteína, pertenece, familia, proteínas, bolsillo, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsbidentificadoressímbolosrbl2. La proteina del retinoblastoma like 2 p130 es un factor de transcripcion codificado en humanos por el gen rbl2 1 2 Esta proteina pertenece a la familia de proteinas bolsillo Proteina del retinoblastoma like 2Estructuras disponiblesPDBBuscar ortologos PDBe RCSBIdentificadoresSimbolosRBL2 HGNC 9894 FLJ26459 P130 Rb2IdentificadoresexternosOMIM 180203EBI RBL2GeneCards Gen RBL2UniProt RBL2LocusCr 16 q12 2 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez5934UniProtQ08999 n aRefSeq ARNm NP 005602 n avte editar datos en Wikidata Indice 1 Interacciones 2 Vease tambien 3 Referencias 4 Enlaces externosInteracciones EditarLa proteina del retinoblastoma like 2 ha demostrado ser capaz de interaccionar con HDAC1 3 4 c Raf 5 RBBP8 6 7 Ciclina E1 8 9 Prohibitina 10 Cdk2 8 11 BRF1 12 BRCA1 13 Vease tambien EditarFamilia de proteinas pocketReferencias Editar Mayol X Grana X Baldi A Sang N Hu Q Giordano A Sep de 1993 Cloning of a new member of the retinoblastoma gene family pRb2 which binds to the E1A transforming domain Oncogene 8 9 2561 6 PMID 8361765 Baldi A Boccia V Claudio PP De Luca A Giordano A Jul de 1996 Genomic structure of the human retinoblastoma related Rb2 p130 gene Proc Natl Acad Sci U S A 93 10 4629 32 PMC 39329 PMID 8643454 Ferreira R Magnaghi Jaulin L Robin P Harel Bellan A Trouche D Sep de 1998 The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase Proc Natl Acad Sci U S A UNITED STATES 95 18 10493 8 ISSN 0027 8424 PMID 9724731 La referencia utiliza el parametro obsoleto coautores ayuda Bouzahzah B Fu M Iavarone A Factor V M Thorgeirsson S S Pestell R G Aug de 2000 Transforming growth factor beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo Cancer Res UNITED STATES 60 16 4531 7 ISSN 0008 5472 PMID 10969803 La referencia utiliza el parametro obsoleto coautores ayuda Wang S Ghosh R N Chellappan S P Dec de 1998 Raf 1 physically interacts with Rb and regulates its function a link between mitogenic signaling and cell cycle regulation Mol Cell Biol UNITED STATES 18 12 7487 98 ISSN 0270 7306 PMID 9819434 La referencia utiliza el parametro obsoleto coautores ayuda Meloni A R Smith E J Nevins J R Aug de 1999 A mechanism for Rb p130 mediated transcription repression involving recruitment of the CtBP corepressor Proc Natl Acad Sci U S A UNITED STATES 96 17 9574 9 ISSN 0027 8424 PMID 10449734 La referencia utiliza el parametro obsoleto coautores ayuda Fusco C Reymond A Zervos A S Aug de 1998 Molecular cloning and characterization of a novel retinoblastoma binding protein Genomics UNITED STATES 51 3 351 8 ISSN 0888 7543 PMID 9721205 doi 10 1006 geno 1998 5368 La referencia utiliza el parametro obsoleto coautores ayuda a b Shanahan F Seghezzi W Parry D Mahony D Lees E Feb de 1999 Cyclin E associates with BAF155 and BRG1 components of the mammalian SWI SNF complex and alters the ability of BRG1 to induce growth arrest Mol Cell Biol UNITED STATES 19 2 1460 9 ISSN 0270 7306 PMID 9891079 Li Y Graham C Lacy S Duncan A M Whyte P Dec de 1993 The adenovirus E1A associated 130 kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E Genes Dev UNITED STATES 7 12A 2366 77 ISSN 0890 9369 PMID 8253383 La referencia utiliza el parametro obsoleto coautores ayuda Wang S Nath N Adlam M Chellappan S Jun de 1999 Prohibitin a potential tumor suppressor interacts with RB and regulates E2F function Oncogene ENGLAND 18 23 3501 10 ISSN 0950 9232 PMID 10376528 doi 10 1038 sj onc 1202684 Lacy S Whyte P mayo de 1997 Identification of a p130 domain mediating interactions with cyclin A cdk 2 and cyclin E cdk 2 complexes Oncogene ENGLAND 14 20 2395 406 ISSN 0950 9232 PMID 9188854 doi 10 1038 sj onc 1201085 Sutcliffe J E Cairns C A McLees A Allison S J Tosh K White R J Jun de 1999 RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 Mol Cell Biol UNITED STATES 19 6 4255 61 ISSN 0270 7306 PMID 10330166 La referencia utiliza el parametro obsoleto coautores ayuda Fan S Yuan R Ma Y X Xiong J Meng Q Erdos M Zhao J N Goldberg I D Pestell R G Rosen E M Aug de 2001 Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding Oncogene England 20 35 4827 41 ISSN 0950 9232 PMID 11521194 doi 10 1038 sj onc 1204666 La referencia utiliza el parametro obsoleto coautores ayuda Enlaces externos EditarMeSH RBL2 protein human en ingles Datos Q18031061Obtenido de https es wikipedia org w index php title Proteina del retinoblastoma like 2 amp oldid 118921239, wikipedia, wiki, leyendo, leer, libro, biblioteca,

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