La proteína de heterocromatina 1 (HP1) es una proteína de unión a metil-lisina localizada en sitios con heterocromatina, donde es responsable del silenciamiento de genes.[2]
Interacciones
La proteína CBX5 ha demostrado ser capaz de interaccionar con:
↑ Ye, Q; Worman H J (Jun. de 1996). «Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1». J. Biol. Chem. (EE. UU.) 271 (25): 14653-6. ISSN 0021-9258. PMID 8663349.
↑ Zhang, Chun Li; McKinsey Timothy A, Olson Eric N (Oct. de 2002). «Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation». Mol. Cell. Biol. (United States) 22 (20): 7302-12. ISSN 0270-7306. PMID 12242305.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Song, K; Jung Y; Jung D; Lee I (Mar. de 2001). «Human Ku70 interacts with heterochromatin protein 1alpha». J. Biol. Chem. (United States) 276 (11): 8321-7. ISSN 0021-9258. PMID 11112778. doi:10.1074/jbc.M008779200.
Obuse, Chikashi; Iwasaki Osamu, Kiyomitsu Tomomi, Goshima Gohta, Toyoda Yusuke, Yanagida Mitsuhiro (Nov. de 2004). «A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1». Nat. Cell Biol. (England) 6 (11): 1135-41. ISSN 1465-7392. PMID 15502821. doi:10.1038/ncb1187.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
↑ Fujita, Naoyuki; Watanabe Sugiko, Ichimura Takaya, Tsuruzoe Shu, Shinkai Yoichi, Tachibana Makoto, Chiba Tsutomu, Nakao Mitsuyoshi (Jun. de 2003). «Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression». J. Biol. Chem. (United States) 278 (26): 24132-8. ISSN 0021-9258. PMID 12711603. doi:10.1074/jbc.M302283200.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
↑ Reese, Brian E; Bachman Kurtis E, Baylin Stephen B, Rountree Michael R (mayo. de 2003). «The methyl-CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1». Mol. Cell. Biol. (United States) 23 (9): 3226-36. ISSN 0270-7306. PMID 12697822.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Vassallo, Milo F; Tanese Naoko (Apr. de 2002). «Isoform-specific interaction of HP1 with human TAFII130». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5919-24. ISSN 0027-8424. PMID 11959914. doi:10.1073/pnas.092025499.
↑ Nielsen, Anders Lade; Sanchez Cecilia, Ichinose Hiroshi, Cerviño Margarita, Lerouge Thierry, Chambon Pierre, Losson Régine (Nov. de 2002). «Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha». EMBO J. (England) 21 (21): 5797-806. ISSN 0261-4189. PMID 12411497.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Cammas, Florence; Oulad-Abdelghani Mustapha, Vonesch Jean-Luc, Huss-Garcia Yolande, Chambon Pierre, Losson Régine (Sep. de 2002). «Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction». J. Cell. Sci. (England) 115 (Pt 17): 3439-48. ISSN 0021-9533. PMID 12154074.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
↑ Nielsen, A L; Oulad-Abdelghani M, Ortiz J A, Remboutsika E, Chambon P, Losson R (Apr. de 2001). «Heterochromatin formation in mammalian cells: interaction between histones and HP1 proteins». Mol. Cell (United States) 7 (4): 729-39. ISSN 1097-2765. PMID 11336697.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
↑ Lechner, M S; Begg G E, Speicher D W, Rauscher F J (Sep. de 2000). «Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential». Mol. Cell. Biol. (UNITED STATES) 20 (17): 6449-65. ISSN 0270-7306. PMID 10938122.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Lehnertz, Bernhard; Ueda Yoshihide, Derijck Alwin A H A, Braunschweig Ulrich, Perez-Burgos Laura, Kubicek Stefan, Chen Taiping, Li En, Jenuwein Thomas, Peters Antoine H F M (Jul. de 2003). «Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin». Curr. Biol. (England) 13 (14): 1192-200. ISSN 0960-9822. PMID 12867029.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. de 2005). «Towards a proteome-scale map of the human protein-protein interaction network». Nature (England) 437 (7062): 1173-8. PMID 16189514. doi:10.1038/nature04209.La referencia utiliza el parámetro obsoleto |coautores= (ayuda)
cbx5, proteína, homóloga, cromobox, proteína, codificada, humanos, proteína, homóloga, cromobox, 5estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsbidentificadoressímbolos, hgnc, 1555, alpha, hp1hs, alphaidentificadoresexternosomim, 604478ebi, genecards,. La proteina homologa cromobox 5 CBX5 es una proteina codificada en humanos por el gen CBX5 1 2 Proteina homologa cromobox 5Estructuras disponiblesPDBBuscar ortologos PDBe RCSBIdentificadoresSimbolosCBX5 HGNC 1555 HP1 HP1 ALPHA HP1Hs alphaIdentificadoresexternosOMIM 604478EBI CBX5GeneCards Gen CBX5UniProt CBX5LocusCr 12 q13 13 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez23468UniProtP45973 n aRefSeq ARNm NP 036249 n avte editar datos en Wikidata La proteina de heterocromatina 1 HP1 es una proteina de union a metil lisina localizada en sitios con heterocromatina donde es responsable del silenciamiento de genes 2 Indice 1 Interacciones 2 Vease tambien 3 Referencias 4 Enlaces externosInteracciones EditarLa proteina CBX5 ha demostrado ser capaz de interaccionar con HDAC9 3 Ku70 4 MIS12 5 Receptor de lamina B 1 MBD1 6 7 TAF4 8 Histona deacetilasa 5 3 TRIM28 9 10 11 12 HDAC4 3 CBX3 11 SMARCA4 9 DNMT3B 13 CHAF1A 7 12 CBX1 11 SUV39H1 6 14 3 Vease tambien EditarProteina de heterocromatina 1Referencias Editar a b Ye Q Worman H J Jun de 1996 Interaction between an integral protein of the nuclear envelope inner membrane and human chromodomain proteins homologous to Drosophila HP1 J Biol Chem EE UU 271 25 14653 6 ISSN 0021 9258 PMID 8663349 a b Entrez Gene CBX5 chromobox homolog 5 HP1 alpha homolog Drosophila a b c d Zhang Chun Li McKinsey Timothy A Olson Eric N Oct de 2002 Association of class II histone deacetylases with heterochromatin protein 1 potential role for histone methylation in control of muscle differentiation Mol Cell Biol United States 22 20 7302 12 ISSN 0270 7306 PMID 12242305 La referencia utiliza el parametro obsoleto coautores ayuda Song K Jung Y Jung D Lee I Mar de 2001 Human Ku70 interacts with heterochromatin protein 1alpha J Biol Chem United States 276 11 8321 7 ISSN 0021 9258 PMID 11112778 doi 10 1074 jbc M008779200 Obuse Chikashi Iwasaki Osamu Kiyomitsu Tomomi Goshima Gohta Toyoda Yusuke Yanagida Mitsuhiro Nov de 2004 A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint 1 Nat Cell Biol England 6 11 1135 41 ISSN 1465 7392 PMID 15502821 doi 10 1038 ncb1187 La referencia utiliza el parametro obsoleto coautores ayuda a b Fujita Naoyuki Watanabe Sugiko Ichimura Takaya Tsuruzoe Shu Shinkai Yoichi Tachibana Makoto Chiba Tsutomu Nakao Mitsuyoshi Jun de 2003 Methyl CpG binding domain 1 MBD1 interacts with the Suv39h1 HP1 heterochromatic complex for DNA methylation based transcriptional repression J Biol Chem United States 278 26 24132 8 ISSN 0021 9258 PMID 12711603 doi 10 1074 jbc M302283200 La referencia utiliza el parametro obsoleto coautores ayuda a b Reese Brian E Bachman Kurtis E Baylin Stephen B Rountree Michael R mayo de 2003 The methyl CpG binding protein MBD1 interacts with the p150 subunit of chromatin assembly factor 1 Mol Cell Biol United States 23 9 3226 36 ISSN 0270 7306 PMID 12697822 La referencia utiliza el parametro obsoleto coautores ayuda Vassallo Milo F Tanese Naoko Apr de 2002 Isoform specific interaction of HP1 with human TAFII130 Proc Natl Acad Sci U S A United States 99 9 5919 24 ISSN 0027 8424 PMID 11959914 doi 10 1073 pnas 092025499 a b Nielsen Anders Lade Sanchez Cecilia Ichinose Hiroshi Cervino Margarita Lerouge Thierry Chambon Pierre Losson Regine Nov de 2002 Selective interaction between the chromatin remodeling factor BRG1 and the heterochromatin associated protein HP1alpha EMBO J England 21 21 5797 806 ISSN 0261 4189 PMID 12411497 La referencia utiliza el parametro obsoleto coautores ayuda Cammas Florence Oulad Abdelghani Mustapha Vonesch Jean Luc Huss Garcia Yolande Chambon Pierre Losson Regine Sep de 2002 Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction J Cell Sci England 115 Pt 17 3439 48 ISSN 0021 9533 PMID 12154074 La referencia utiliza el parametro obsoleto coautores ayuda a b c Nielsen A L Oulad Abdelghani M Ortiz J A Remboutsika E Chambon P Losson R Apr de 2001 Heterochromatin formation in mammalian cells interaction between histones and HP1 proteins Mol Cell United States 7 4 729 39 ISSN 1097 2765 PMID 11336697 La referencia utiliza el parametro obsoleto coautores ayuda a b Lechner M S Begg G E Speicher D W Rauscher F J Sep de 2000 Molecular determinants for targeting heterochromatin protein 1 mediated gene silencing direct chromoshadow domain KAP 1 corepressor interaction is essential Mol Cell Biol UNITED STATES 20 17 6449 65 ISSN 0270 7306 PMID 10938122 La referencia utiliza el parametro obsoleto coautores ayuda Lehnertz Bernhard Ueda Yoshihide Derijck Alwin A H A Braunschweig Ulrich Perez Burgos Laura Kubicek Stefan Chen Taiping Li En Jenuwein Thomas Peters Antoine H F M Jul de 2003 Suv39h mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin Curr Biol England 13 14 1192 200 ISSN 0960 9822 PMID 12867029 La referencia utiliza el parametro obsoleto coautores ayuda Rual Jean Francois Venkatesan Kavitha Hao Tong Hirozane Kishikawa Tomoko Dricot Amelie Li Ning Berriz Gabriel F Gibbons Francis D Dreze Matija Ayivi Guedehoussou Nono Klitgord Niels Simon Christophe Boxem Mike Milstein Stuart Rosenberg Jennifer Goldberg Debra S Zhang Lan V Wong Sharyl L Franklin Giovanni Li Siming Albala Joanna S Lim Janghoo Fraughton Carlene Llamosas Estelle Cevik Sebiha Bex Camille Lamesch Philippe Sikorski Robert S Vandenhaute Jean Zoghbi Huda Y Smolyar Alex Bosak Stephanie Sequerra Reynaldo Doucette Stamm Lynn Cusick Michael E Hill David E Roth Frederick P Vidal Marc Oct de 2005 Towards a proteome scale map of the human protein protein interaction network Nature England 437 7062 1173 8 PMID 16189514 doi 10 1038 nature04209 La referencia utiliza el parametro obsoleto coautores ayuda Enlaces externos EditarMeSH CBX5 protein human en ingles Datos Q18037200Obtenido de https es wikipedia org w index php title CBX5 amp oldid 118921484, wikipedia, wiki, leyendo, leer, libro, biblioteca,
