El receptor de melatonina tipo 1A es una proteína que en humanos se codifica por el genMTNR1A ubicado en el cromosoma 4 (humano) con localización 4q35.2 .[1] [2]
El receptor ML1A o Mel-1A-R (antes llamado MT1) es un receptor con alta afinidad por la melatonina. Es mediador en las acciones circadianas y reproductivas de la melatonina.[3]
Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (Nov de 1995). «Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)». Genomics27 (2): 355-357. PMID 7558006. doi:10.1006/geno.1995.1056.
«Entrez Gene: MTNR1A melatonin receptor 1A».
«Mel-1A-R». Uniprot. 2019. Consultado el 30 de agosto de 2020.
Enlaces externos
«Melatonin Receptors: MT1». IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
Léase también
Brzezinski A (1997). «Melatonin in humans.». N. Engl. J. Med.336 (3): 186-95. PMID 8988899.
Reppert SM, Weaver DR, Ebisawa T (1994). «Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses.». Neuron13 (5): 1177-85. PMID 7946354.
Witt-Enderby PA, Dubocovich ML (1996). «Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.». Mol. Pharmacol.50 (1): 166-74. PMID 8700109.
Witt-Enderby PA, Masana MI, Dubocovich ML (1998). «Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor.». Endocrinology139 (7): 3064-71. PMID 9645677.
Ebisawa T, Kajimura N, Uchiyama M, et al. (1999). «Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders.». Biochem. Biophys. Res. Commun.262 (3): 832-7. PMID 10471411. doi:10.1006/bbrc.1999.1308.
Brydon L, Roka F, Petit L, et al. (2000). «Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins.». Mol. Endocrinol.13 (12): 2025-38. PMID 10598579.
Niles LP, Wang J, Shen L, et al. (2000). «Melatonin receptor mRNA expression in human granulosa cells.». Mol. Cell. Endocrinol.156 (1-2): 107-10. PMID 10612428.
Song CK, Bartness TJ (2001). «CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity.». Am. J. Physiol. Regul. Integr. Comp. Physiol.281 (2): R666-72. PMID 11448873.
Roy D, Angelini NL, Fujieda H, et al. (2001). «Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.». Endocrinology142 (11): 4711-20. PMID 11606436.
Savaskan E, Olivieri G, Meier F, et al. (2002). «Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients.». J. Pineal Res.32 (1): 59-62. PMID 11841602.
Savaskan E, Wirz-Justice A, Olivieri G, et al. (2002). «Distribution of melatonin MT1 receptor immunoreactivity in human retina.». J. Histochem. Cytochem.50 (4): 519-26. PMID 11897804.
Ayoub MA, Couturier C, Lucas-Meunier E, et al. (2002). «Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.». J. Biol. Chem.277 (24): 21522-8. PMID 11940583. doi:10.1074/jbc.M200729200.
Yuan L, Collins AR, Dai J, et al. (2003). «MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.». Mol. Cell. Endocrinol.192 (1-2): 147-56. PMID 12088876.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899-903. PMID 12477932. doi:10.1073/pnas.242603899.
Slominski A, Pisarchik A, Zbytek B, et al. (2003). «Functional activity of serotoninergic and melatoninergic systems expressed in the skin.». J. Cell. Physiol.196 (1): 144-53. PMID 12767050. doi:10.1002/jcp.10287.
Morcuende JA, Minhas R, Dolan L, et al. (2004). «Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis.». Spine28 (17): 2025-8; discussion 2029. PMID 12973153. doi:10.1097/01.BRS.0000083235.74593.49.
Aust S, Thalhammer T, Humpeler S, et al. (2004). «The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia.». J. Pineal Res.36 (1): 43-8. PMID 14675129.
Datos:Q18029573
Noviembre 19, 2021
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El receptor de melatonina tipo 1A es una proteina que en humanos se codifica por el gen MTNR1A ubicado en el cromosoma 4 humano con localizacion 4q35 2 1 2 Receptor de melatonina 1AEstructuras disponiblesPDBBuscar ortologos PDBe RCSBIdentificadoresSimboloMTNR1A HGNC 7463 IdentificadoresexternosOMIM 600665EBI MTNR1AGeneCards Gen MTNR1AUniProt MTNR1ALocusCr 4 q35 1 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez4543UniProtP48039 n aRefSeq ARNm NM 005958 n avte editar datos en Wikidata Indice 1 Funciones 2 Vease tambien 3 Referencias 4 Enlaces externos 5 Lease tambienFunciones EditarEl receptor ML1A o Mel 1A R antes llamado MT1 es un receptor con alta afinidad por la melatonina Es mediador en las acciones circadianas y reproductivas de la melatonina 3 Vease tambien Editarreceptor de melatonina receptor de melatonina 1BReferencias Editar Slaugenhaupt SA Roca AL Liebert CB Altherr MR Gusella JF Reppert SM Nov de 1995 Mapping of the gene for the Mel1a melatonin receptor to human chromosome 4 MTNR1A and mouse chromosome 8 Mtnr1a Genomics 27 2 355 357 PMID 7558006 doi 10 1006 geno 1995 1056 Entrez Gene MTNR1A melatonin receptor 1A Mel 1A R Uniprot 2019 Consultado el 30 de agosto de 2020 Enlaces externos Editar Melatonin Receptors MT1 IUPHAR Database of Receptors and Ion Channels International Union of Basic and Clinical Pharmacology Lease tambien EditarBrzezinski A 1997 Melatonin in humans N Engl J Med 336 3 186 95 PMID 8988899 Khan AU Olson DL 1975 Physical therapy and exercise induced bronchospasm Physical therapy 55 8 878 81 PMID 1144527 Reppert SM Weaver DR Ebisawa T 1994 Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses Neuron 13 5 1177 85 PMID 7946354 Witt Enderby PA Dubocovich ML 1996 Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells Mol Pharmacol 50 1 166 74 PMID 8700109 Witt Enderby PA Masana MI Dubocovich ML 1998 Physiological exposure to melatonin supersensitizes the cyclic adenosine 3 5 monophosphate dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor Endocrinology 139 7 3064 71 PMID 9645677 Ebisawa T Kajimura N Uchiyama M et al 1999 Alleic variants of human melatonin 1a receptor function and prevalence in subjects with circadian rhythm sleep disorders Biochem Biophys Res Commun 262 3 832 7 PMID 10471411 doi 10 1006 bbrc 1999 1308 Brydon L Roka F Petit L et al 2000 Dual signaling of human Mel1a melatonin receptors via G i2 G i3 and G q 11 proteins Mol Endocrinol 13 12 2025 38 PMID 10598579 Niles LP Wang J Shen L et al 2000 Melatonin receptor mRNA expression in human granulosa cells Mol Cell Endocrinol 156 1 2 107 10 PMID 10612428 Song CK Bartness TJ 2001 CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity Am J Physiol Regul Integr Comp Physiol 281 2 R666 72 PMID 11448873 Roy D Angelini NL Fujieda H et al 2001 Cyclical regulation of GnRH gene expression in GT1 7 GnRH secreting neurons by melatonin Endocrinology 142 11 4711 20 PMID 11606436 Savaskan E Olivieri G Meier F et al 2002 Increased melatonin 1a receptor immunoreactivity in the hippocampus of Alzheimer s disease patients J Pineal Res 32 1 59 62 PMID 11841602 Savaskan E Wirz Justice A Olivieri G et al 2002 Distribution of melatonin MT1 receptor immunoreactivity in human retina J Histochem Cytochem 50 4 519 26 PMID 11897804 Ayoub MA Couturier C Lucas Meunier E et al 2002 Monitoring of ligand independent dimerization and ligand induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer J Biol Chem 277 24 21522 8 PMID 11940583 doi 10 1074 jbc M200729200 Yuan L Collins AR Dai J et al 2003 MT 1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells Mol Cell Endocrinol 192 1 2 147 56 PMID 12088876 Strausberg RL Feingold EA Grouse LH et al 2003 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 PMID 12477932 doi 10 1073 pnas 242603899 Slominski A Pisarchik A Zbytek B et al 2003 Functional activity of serotoninergic and melatoninergic systems expressed in the skin J Cell Physiol 196 1 144 53 PMID 12767050 doi 10 1002 jcp 10287 Morcuende JA Minhas R Dolan L et al 2004 Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis Spine 28 17 2025 8 discussion 2029 PMID 12973153 doi 10 1097 01 BRS 0000083235 74593 49 Aust S Thalhammer T Humpeler S et al 2004 The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia J Pineal Res 36 1 43 8 PMID 14675129 Datos Q18029573 Obtenido de https es wikipedia org w index php title Receptor de melatonina 1A amp oldid 128889218, wikipedia, wiki, leyendo, leer, libro, biblioteca,
