La proteína codificada por este gen es un miembro del cyclin-proteína dependiente kinase (CDK) familia. CDK Los miembros familiares son altamente similares a los productos de gen de Saccharomyces cerevisiae cdc28, y Schizosaccharomyces pombe cdc2, y es sabido de ser reguladores importantes de progresión de ciclo de la célula. Esta proteína forma un complejo trimerico con la cyclin H y MAT1, el cual funciona como Cdk-activando kinase (CAK). Es un componente esencial del factor de transcripción TFIIH, implicado en la iniciación de la transcripción y reparación del ADN. Se piensa que esta quinasa sirve como enlace directo entre el control de transcripción y el ciclo celular.[2]
Interacciones
La Cdk 7 ha demostrado ser capaz de interaccionar con:
Fisher RP, Morgan DO (Aug 1994). «A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase». Cell78 (4): 713-24. PMID 8069918. doi:10.1016/0092-8674(94)90535-5.
Lee DK, Duan HO, Chang C (Mar 2000). «From androgen receptor to the general transcription factor TFIIH. Identification of cdk activating kinase (CAK) as an androgen receptor NH(2)-terminal associated coactivator». The Journal of Biological Chemistry275 (13): 9308-13. PMID 10734072. doi:10.1074/jbc.275.13.9308.
↑ Yee A, Nichols MA, Wu L, Hall FL, Kobayashi R, Xiong Y (Dec 1995). «Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor». Cancer Research55 (24): 6058-62. PMID 8521393.
Mäkelä TP, Tassan JP, Nigg EA, Frutiger S, Hughes GJ, Weinberg RA (Sep 1994). «A cyclin associated with the CDK-activating kinase MO15». Nature371 (6494): 254-7. PMID 8078587. doi:10.1038/371254a0.
↑ Garber ME, Mayall TP, Suess EM, Meisenhelder J, Thompson NE, Jones KA (Sep 2000). «CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA». Molecular and Cellular Biology20 (18): 6958-69. PMC 88771. PMID 10958691. doi:10.1128/mcb.20.18.6958-6969.2000.
↑ Rossignol M, Kolb-Cheynel I, Egly JM (Apr 1997). «Substrate specificity of the cdk-activating kinase (CAK) is altered upon association with TFIIH». The EMBO Journal16 (7): 1628-37. PMC 1169767. PMID 9130708. doi:10.1093/emboj/16.7.1628.
Shiekhattar R, Mermelstein F, Fisher RP, Drapkin R, Dynlacht B, Wessling HC, Morgan DO, Reinberg D (Mar 1995). «Cdk-activating kinase complex is a component of human transcription factor TFIIH». Nature374 (6519): 283-7. PMID 7533895. doi:10.1038/374283a0.
Talukder AH, Mishra SK, Mandal M, Balasenthil S, Mehta S, Sahin AA, Barnes CJ, Kumar R (Mar 2003). «MTA1 interacts with MAT1, a cyclin-dependent kinase-activating kinase complex ring finger factor, and regulates estrogen receptor transactivation functions». The Journal of Biological Chemistry278 (13): 11676-85. PMID 12527756. doi:10.1074/jbc.M209570200.
Ko LJ, Shieh SY, Chen X, Jayaraman L, Tamai K, Taya Y, Prives C, Pan ZQ (Dec 1997). «p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner». Molecular and Cellular Biology17 (12): 7220-9. PMC 232579. PMID 9372954.
Schneider E, Montenarh M, Wagner P (Nov 1998). «Regulation of CAK kinase activity by p53». Oncogene17 (21): 2733-41. PMID 9840937. doi:10.1038/sj.onc.1202504.
Giglia-Mari G, Coin F, Ranish JA, Hoogstraten D, Theil A, Wijgers N, Jaspers NG, Raams A, Argentini M, van der Spek PJ, Botta E, Stefanini M, Egly JM, Aebersold R, Hoeijmakers JH, Vermeulen W (Jul 2004). «A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A». Nature Genetics36 (7): 714-9. PMID 15220921. doi:10.1038/ng1387.
Datos:Q18021240
Febrero 18, 2023
cdk7, proteína, división, célula, kinase, enzima, humanos, codificada, cdk7, quinasa, dependiente, ciclina, 7imagen, basada, 1ua2, estructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsb, lista, códigos, pdb1lg3, 1pa8, 1ua2, 2hic, estructuras, enzimáticasrcsb. Proteina de division de la celula kinase 7 es una enzima que en los humanos es codificada por el gen CDK7 1 Quinasa dependiente de ciclina 7Imagen del PDB basada en 1ua2 Estructuras disponiblesPDBBuscar ortologos PDBe RCSB Lista de codigos PDB1LG3 1PA8 1UA2 2HIC Estructuras enzimaticasRCSB PDB PDBe PDBsumIdentificadoresSimbolosCdk7 HGNC 1778 CAK1 CDKN7 HCAK MO15 STK1 p39MO15IdentificadoresexternosOMIM 601955MGI 102956HomoloGene 1363ChEMBL 3055EBI Cdk7GeneCards Gen Cdk7UniProt Cdk7 Bases de datos de enzimasIntEnz entrada en IntEnz BRENDA entrada en BRENDA ExPASy NiceZime view KEGG entrada en KEEG PRIAM perfil PRIAM ExplorEnz entrada en ExplorEnz MetaCyc via metabolicaNumero EC2 7 11LocusCr 5 q12 1 Ontologia genicaFuncion molecular transcription coactivator activity protein kinase activity cyclin dependent protein serine threonine kinase activity protein binding ATP binding protein C terminus binding DNA dependent ATPase activity RNA polymerase II carboxy terminal domain kinase activity androgen receptor bindingComponente celular nucleus nucleoplasm holo TFIIH complex cytoplasm mitochondrion perinuclear region of cytoplasmProceso biologico regulation of cyclin dependent protein serine threonine kinase activity G1 S transition of mitotic cell cycle G2 M transition of mitotic cell cycle mitotic cell cycle nucleotide excision repair DNA damage removal DNA repair transcription coupled nucleotide excision repair nucleotide excision repair transcription from RNA polymerase I promoter transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase I promoter termination of RNA polymerase I transcription transcription from RNA polymerase II promoter transcription initiation from RNA polymerase II promoter transcription elongation from RNA polymerase II promoter 7 methylguanosine mRNA capping protein phosphorylation cell cycle arrest cell proliferation gene expression viral process androgen receptor signaling pathway regulation of gene expression epigenetic negative regulation of gene expression epigenetic positive regulation of transcription DNA templated positive regulation of transcription from RNA polymerase II promoter positive regulation of viral transcription cell divisionReferencias AmiGO QuickGOPatron de expresion de ARNmMas informacionOrtologosEspeciesHumano RatonEntrez1022 12572EnsemblVease HS Vease MMUniProtP50613 Q03147RefSeq ARNm NM 001799 NM 009874RefSeq proteina NCBINP 001790 NP 034004Ubicacion UCSC Cr 5 69 23 69 28 Mb Cr 13 100 7 100 73 MbPubMed Busqueda 1 2 vte editar datos en Wikidata La proteina codificada por este gen es un miembro del cyclin proteina dependiente kinase CDK familia CDK Los miembros familiares son altamente similares a los productos de gen de Saccharomyces cerevisiae cdc28 y Schizosaccharomyces pombe cdc2 y es sabido de ser reguladores importantes de progresion de ciclo de la celula Esta proteina forma un complejo trimerico con la cyclin H y MAT1 el cual funciona como Cdk activando kinase CAK Es un componente esencial del factor de transcripcion TFIIH implicado en la iniciacion de la transcripcion y reparacion del ADN Se piensa que esta quinasa sirve como enlace directo entre el control de transcripcion y el ciclo celular 2 Interacciones EditarLa Cdk 7 ha demostrado ser capaz de interaccionar con Receptor androgenico 3 Ciclina H 4 5 6 GTF2H1 7 4 8 MNAT1 4 9 P53 10 11 SUPT5H 6 and XPB 12 7 4 Referencias Editar Fisher RP Morgan DO Aug 1994 A novel cyclin associates with MO15 CDK7 to form the CDK activating kinase Cell 78 4 713 24 PMID 8069918 doi 10 1016 0092 8674 94 90535 5 Entrez Gene CDK7 cyclin dependent kinase 7 MO15 homolog Xenopus laevis cdk activating kinase Lee DK Duan HO Chang C Mar 2000 From androgen receptor to the general transcription factor TFIIH Identification of cdk activating kinase CAK as an androgen receptor NH 2 terminal associated coactivator The Journal of Biological Chemistry 275 13 9308 13 PMID 10734072 doi 10 1074 jbc 275 13 9308 a b c d Yee A Nichols MA Wu L Hall FL Kobayashi R Xiong Y Dec 1995 Molecular cloning of CDK7 associated human MAT1 a cyclin dependent kinase activating kinase CAK assembly factor Cancer Research 55 24 6058 62 PMID 8521393 Makela TP Tassan JP Nigg EA Frutiger S Hughes GJ Weinberg RA Sep 1994 A cyclin associated with the CDK activating kinase MO15 Nature 371 6494 254 7 PMID 8078587 doi 10 1038 371254a0 a b Garber ME Mayall TP Suess EM Meisenhelder J Thompson NE Jones KA Sep 2000 CDK9 autophosphorylation regulates high affinity binding of the human immunodeficiency virus type 1 tat P TEFb complex to TAR RNA Molecular and Cellular Biology 20 18 6958 69 PMC 88771 PMID 10958691 doi 10 1128 mcb 20 18 6958 6969 2000 a b Rossignol M Kolb Cheynel I Egly JM Apr 1997 Substrate specificity of the cdk activating kinase CAK is altered upon association with TFIIH The EMBO Journal 16 7 1628 37 PMC 1169767 PMID 9130708 doi 10 1093 emboj 16 7 1628 Shiekhattar R Mermelstein F Fisher RP Drapkin R Dynlacht B Wessling HC Morgan DO Reinberg D Mar 1995 Cdk activating kinase complex is a component of human transcription factor TFIIH Nature 374 6519 283 7 PMID 7533895 doi 10 1038 374283a0 Talukder AH Mishra SK Mandal M Balasenthil S Mehta S Sahin AA Barnes CJ Kumar R Mar 2003 MTA1 interacts with MAT1 a cyclin dependent kinase activating kinase complex ring finger factor and regulates estrogen receptor transactivation functions The Journal of Biological Chemistry 278 13 11676 85 PMID 12527756 doi 10 1074 jbc M209570200 Ko LJ Shieh SY Chen X Jayaraman L Tamai K Taya Y Prives C Pan ZQ Dec 1997 p53 is phosphorylated by CDK7 cyclin H in a p36MAT1 dependent manner Molecular and Cellular Biology 17 12 7220 9 PMC 232579 PMID 9372954 Schneider E Montenarh M Wagner P Nov 1998 Regulation of CAK kinase activity by p53 Oncogene 17 21 2733 41 PMID 9840937 doi 10 1038 sj onc 1202504 Giglia Mari G Coin F Ranish JA Hoogstraten D Theil A Wijgers N Jaspers NG Raams A Argentini M van der Spek PJ Botta E Stefanini M Egly JM Aebersold R Hoeijmakers JH Vermeulen W Jul 2004 A new tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group A Nature Genetics 36 7 714 9 PMID 15220921 doi 10 1038 ng1387 Datos Q18021240 Obtenido de https es wikipedia org w index php title Cdk7 amp oldid 143022843, wikipedia, wiki, leyendo, leer, libro, biblioteca,
