La subunidad beta hormona estimulante de la tiroides, también conocida como TSHB (del inglés: Thyroid stimulating hormone, beta) es una proteína que en humanos es codificada por el genTSHB.[1][2]
La TSH es una glicoproteína heterodímero ligada no covalentemente y es parte de la familia de hormonas pituitarias conteniendo una subunidad alfa común (TSHA) y una subunidad beta única (esta proteína) que confiere especificidad.[3]
Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (septiembre de 1988). «Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species». J. Biol. Chem.263 (25): 12538-42. PMID 2457586.
Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (diciembre de 1988). «The structure of the human thyrotropin beta-subunit gene». Gene73 (2): 489-97. PMID 3243440. doi:10.1016/0378-1119(88)90513-6.
«Entrez Gene: TSHB».
Lectura adicional (en inglés)editar
Bonomi M, Proverbio MC, Weber G, et al. (2001). «Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene.». J. Clin. Endocrinol. Metab.86 (4): 1600-4. PMID 11297590. doi:10.1210/jc.86.4.1600.
Vuissoz JM, Deladoëy J, Buyukgebiz A, et al. (2001). «New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism.». J. Clin. Endocrinol. Metab.86 (9): 4468-71. PMID 11549695. doi:10.1210/jc.86.9.4468.
Karges B, LeHeup B, Schoenle E, et al. (2004). «Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe.». Horm. Res.62 (3): 149-55. PMID 15297803. doi:10.1159/000080071.
Kabadi UM, Premachandra BN (2007). «Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?». Endocr Pract13 (6): 615-9. PMID 17954417.
Miyai S, Yoshimura S, Iwasaki Y, et al. (2005). «Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line.». Cell Tissue Res.322 (2): 269-77. PMID 16133148. doi:10.1007/s00441-005-0033-z.
Pierce JG (1971). «Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones.». Endocrinology89 (6): 1331-44. PMID 5002675. doi:10.1210/endo-89-6-1331.
Atzmon G, Barzilai N, Surks MI, Gabriely I (2009). «Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.». J. Clin. Endocrinol. Metab.94 (12): 4768-75. PMC 2795660. PMID 19837933. doi:10.1210/jc.2009-0808.
Landa I, Ruiz-Llorente S, Montero-Conde C, et al. (2009). «The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.». PLoS Genet.5 (9): e1000637. PMC 2727793. PMID 19730683. doi:10.1371/journal.pgen.1000637.
Pohlenz J, Dumitrescu A, Aumann U, et al. (2002). «Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene.». J. Clin. Endocrinol. Metab.87 (1): 336-9. PMID 11788671. doi:10.1210/jc.87.1.336.
Miyoshi I, Kasai N, Hayashizaki Y (1994). «[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]». Nippon Rinsho52 (4): 940-7. PMID 8196184.
Borck G, Topaloglu AK, Korsch E, et al. (2004). «Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect.». J. Clin. Endocrinol. Metab.89 (8): 4136-41. PMID 15292359. doi:10.1210/jc.2004-0494.
Comings DE, Gade-Andavolu R, Gonzalez N, et al. (2000). «A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory.». Clin. Genet.58 (5): 375-85. PMID 11140838. doi:10.1034/j.1399-0004.2000.580508.x.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). «The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).». Genome Res.14 (10B): 2121-7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Clark AG, Glanowski S, Nielsen R, et al. (2003). «Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.». Science302 (5652): 1960-3. PMID 14671302. doi:10.1126/science.1088821.
Loinder K, Söderström M (2005). «An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene.». J. Steroid Biochem. Mol. Biol.97 (4): 322-7. PMID 16216492. doi:10.1016/j.jsbmb.2005.06.031.
Luttrell LM (2008). «Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.». Mol. Biotechnol.39 (3): 239-64. PMID 18240029. doi:10.1007/s12033-008-9031-1.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.». Proc. Natl. Acad. Sci. U.S.A.99 (26): 16899-903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Brumm H, Pfeufer A, Biebermann H, et al. (2002). «Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect.». J. Clin. Endocrinol. Metab.87 (10): 4811-6. PMID 12364478. doi:10.1210/jc.2002-020297.
Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). «Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death.». Eur. J. Endocrinol.160 (6): 985-91. PMID 19273570. doi:10.1530/EJE-08-0953.
Schaefer JS, Klein JR (2009). «A novel thyroid stimulating hormone beta-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid.». Gen. Comp. Endocrinol.162 (3): 241-4. PMC 2689139. PMID 19364510. doi:10.1016/j.ygcen.2009.04.006.
Datos:Q18032201
Marcha 31, 2024
tshb, subunidad, beta, hormona, estimulante, tiroides, también, conocida, como, inglés, thyroid, stimulating, hormone, beta, proteína, humanos, codificada, hormona, estimulante, tiroides, betaestructuras, disponiblespdbbuscar, ortólogos, pdbe, rcsbidentificado. La subunidad beta hormona estimulante de la tiroides tambien conocida como TSHB del ingles Thyroid stimulating hormone beta es una proteina que en humanos es codificada por el gen TSHB 1 2 Hormona estimulante de la tiroides betaEstructuras disponiblesPDBBuscar ortologos PDBe RCSBIdentificadoresSimboloTSHB HGNC 12372 IdentificadoresexternosOMIM 188540EBI TSHBGeneCards Gen TSHBUniProt TSHBLocusCr 1 p13 Ontologia genicaReferencias AmiGO QuickGOOrtologosEspeciesHumano RatonEntrez7252UniProtP01222 n aRefSeq ARNm NM 000549 n avte editar datos en Wikidata Indice 1 Funcion 2 Vease tambien 3 Referencias 4 Lectura adicional en ingles Funcion editarLa TSH es una glicoproteina heterodimero ligada no covalentemente y es parte de la familia de hormonas pituitarias conteniendo una subunidad alfa comun TSHA y una subunidad beta unica esta proteina que confiere especificidad 3 Vease tambien editarHormona estimulante de la tiroidesReferencias editar Wondisford FE Radovick S Moates JM Usala SJ Weintraub BD septiembre de 1988 Isolation and characterization of the human thyrotropin beta subunit gene Differences in gene structure and promoter function from murine species J Biol Chem 263 25 12538 42 PMID 2457586 Tatsumi K Hayashizaki Y Hiraoka Y Miyai K Matsubara K diciembre de 1988 The structure of the human thyrotropin beta subunit gene Gene 73 2 489 97 PMID 3243440 doi 10 1016 0378 1119 88 90513 6 Entrez Gene TSHB Lectura adicional en ingles editarBonomi M Proverbio MC Weber G et al 2001 Hyperplastic pituitary gland high serum glycoprotein hormone alpha subunit and variable circulating thyrotropin TSH levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene J Clin Endocrinol Metab 86 4 1600 4 PMID 11297590 doi 10 1210 jc 86 4 1600 Vuissoz JM Deladoey J Buyukgebiz A et al 2001 New autosomal recessive mutation of the TSH beta subunit gene causing central isolated hypothyroidism J Clin Endocrinol Metab 86 9 4468 71 PMID 11549695 doi 10 1210 jc 86 9 4468 Karges B LeHeup B Schoenle E et al 2004 Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe Horm Res 62 3 149 55 PMID 15297803 doi 10 1159 000080071 Kabadi UM Premachandra BN 2007 Serum thyrotropin in Graves disease a more reliable index of circulating thyroid stimulating immunoglobulin level than thyroid function Endocr Pract 13 6 615 9 PMID 17954417 Miyai S Yoshimura S Iwasaki Y et al 2005 Induction of GH PRL and TSH beta mRNA by transfection of Pit 1 in a human pituitary adenoma derived cell line Cell Tissue Res 322 2 269 77 PMID 16133148 doi 10 1007 s00441 005 0033 z Pierce JG 1971 Eli Lilly lecture The subunits of pituitary thyrotropin their relationship to other glycoprotein hormones Endocrinology 89 6 1331 44 PMID 5002675 doi 10 1210 endo 89 6 1331 Atzmon G Barzilai N Surks MI Gabriely I 2009 Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity J Clin Endocrinol Metab 94 12 4768 75 PMC 2795660 PMID 19837933 doi 10 1210 jc 2009 0808 Landa I Ruiz Llorente S Montero Conde C et al 2009 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1 USF2 transcription factors PLoS Genet 5 9 e1000637 PMC 2727793 PMID 19730683 doi 10 1371 journal pgen 1000637 Pohlenz J Dumitrescu A Aumann U et al 2002 Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta subunit gene J Clin Endocrinol Metab 87 1 336 9 PMID 11788671 doi 10 1210 jc 87 1 336 Miyoshi I Kasai N Hayashizaki Y 1994 Structure and regulation of human thyroid stimulating hormone TSH gene Nippon Rinsho 52 4 940 7 PMID 8196184 Borck G Topaloglu AK Korsch E et al 2004 Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin beta gene phenotypic variability and founder effect J Clin Endocrinol Metab 89 8 4136 41 PMID 15292359 doi 10 1210 jc 2004 0494 Comings DE Gade Andavolu R Gonzalez N et al 2000 A multivariate analysis of 59 candidate genes in personality traits the temperament and character inventory Clin Genet 58 5 375 85 PMID 11140838 doi 10 1034 j 1399 0004 2000 580508 x Gerhard DS Wagner L Feingold EA et al 2004 The status quality and expansion of the NIH full length cDNA project the Mammalian Gene Collection MGC Genome Res 14 10B 2121 7 PMC 528928 PMID 15489334 doi 10 1101 gr 2596504 Clark AG Glanowski S Nielsen R et al 2003 Inferring nonneutral evolution from human chimp mouse orthologous gene trios Science 302 5652 1960 3 PMID 14671302 doi 10 1126 science 1088821 Loinder K Soderstrom M 2005 An LXXLL motif in nuclear receptor corepressor mediates ligand induced repression of the thyroid stimulating hormone beta gene J Steroid Biochem Mol Biol 97 4 322 7 PMID 16216492 doi 10 1016 j jsbmb 2005 06 031 Luttrell LM 2008 Reviews in molecular biology and biotechnology transmembrane signaling by G protein coupled receptors Mol Biotechnol 39 3 239 64 PMID 18240029 doi 10 1007 s12033 008 9031 1 Strausberg RL Feingold EA Grouse LH et al 2002 Generation and initial analysis of more than 15 000 full length human and mouse cDNA sequences Proc Natl Acad Sci U S A 99 26 16899 903 PMC 139241 PMID 12477932 doi 10 1073 pnas 242603899 Brumm H Pfeufer A Biebermann H et al 2002 Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect J Clin Endocrinol Metab 87 10 4811 6 PMID 12364478 doi 10 1210 jc 2002 020297 Benhadi N Wiersinga WM Reitsma JB et al 2009 Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage fetal or neonatal death Eur J Endocrinol 160 6 985 91 PMID 19273570 doi 10 1530 EJE 08 0953 Schaefer JS Klein JR 2009 A novel thyroid stimulating hormone beta subunit isoform in human pituitary peripheral blood leukocytes and thyroid Gen Comp Endocrinol 162 3 241 4 PMC 2689139 PMID 19364510 doi 10 1016 j ygcen 2009 04 006 nbsp Datos Q18032201 Obtenido de https es wikipedia org w index php title TSHB amp oldid 142405690, wikipedia, wiki, leyendo, leer, libro, biblioteca,
